儿童与迟发性女性痤疮患者血清性激素水平的比较

COMPARISON OF THE SERUM SEX HORMONE LEV ELS BETWEEN CHILDREN AND IN WOMEN WITH LATE ONSET ACNE

[目的]通过检测儿童与迟发性女性寻常痤疮患者体内性激素水平,探讨性激素与痤疮发病的关系。[方法]采用电化学发光免疫分析法对25例儿童女性痤疮患者及20例迟发性女性痤疮患者血清6项性激素水平进行检测,并分别与相应年龄段的正常女性各18例作对照。[结果]儿童女性痤疮患者血清雌二醇水平低于同龄正常对照组(P﹤0.05);睾酮/雌二醇比值及促卵泡素均高于正常对照组(P﹤0.05);女性迟发性痤疮患者血清睾酮水平较相应年龄的正常对照组显著升高(P﹤0.01)。[结论]儿童女性痤疮发病的主要原因可能是由于雌激素分泌不足,血清内睾酮水平相对增多所致。女性迟发性痤疮发病的主要原因则可能与雄激素分泌增多有关。

[Objective] To explore the relationship between sex hormones and acne onset by detecting the sex hormone levels in children and women with late onset acne vulgaris. [ Methods] Electrochemiluminescence immunoassay was used to determine six items of sex hormones in 25 cases of female Children and 20 cases of women with late onset acne, respectively compared with 18 cases of normal females at the corresponding ages, [ Results] The serum estradiol levels of female children with ache were significantly lower than that of the control group at the same age （P 〈 0.05） ; the rates of testosterone and estradiol of the patients were significantly higher than those of the normal control group （P 〈 0.05） ; follicle-stimulating hormone （FSH） Was also higher than that of the normal control group （P 〈 0,05） ; the serum testosterone levels of women with late onset ache were significantly higher than that of the control group at the corresponding ages （P 〈 0.01 ）. [ Conclusion ] The main rea son for female children＇ s acne would be the inadequate estrogen secretion causes the increasing in the Serum testosterone, while the main cause of females with late onset acne may be related to the increasing in the androgen secretion.