β-N,N-二苄基氨基高烯丙醇的合成

Synthesis of β-N,N-dibenzylamino homoallylic alcohols

以天然氨基酸为原料,经还原、氨基保护S、wern氧化得到α-氨基醛,再与烯丙基溴化钐反应,高立体选择性的得到5个分子内含两个手性中心的手性氨基醇。产物结构通过IR和1HNMR确证。该反应具有操作简单、反应条件温和、产率高、选择性强等优点,为合成手性氨基醇提供了有效方法。

Five β-N,N-dibenzylamino homoallylic alcohols with two chiral centers were synthesized using natural α-amino acids as starting materials through several steps.The addition of α-N,N-dibenzylamino aldehyde with allylsamarium bromide was tested.The structures of the target products were characterized by FT-IR and ^1HNMR.This method was proved to be an efficient,mild and useful one for the synthesis of chiral β-amino alcohols.