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硫酸头孢喹诺的合成 被引量：7

Synthesis of cefquinome sulfate
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摘要 以头孢噻肟酸为原料,经3位取代、成盐、离子交换、硫酸成盐,最终得到标题化合物,总收率35.9%。其结构经1HNMR确证。本合成方法原料易得,便于工业化生产。 Cefquinome sulfate was prepared from cefotaxime via 3-substitution,salt formation,and salt exchange with sulfuric acid by anion exchange resin.The total yield of cefquinome sulfate was 35.9%,and its structure was confirmed by 1HNMR.The route for synthesis of cefquinome sulfate was convenient in terms of raw materials availability and commercial scale manufacture.
作者 杨美丽 郑国钧
机构地区 北京化工大学生命科学与技术学院
出处 《化学试剂》 CAS CSCD 北大核心 2008年第10期787-788,共2页 Chemical Reagents
关键词 头孢喹诺 头孢噻肟酸 抗生素 合成 cefquinome cefotaxime antibiotic synthesis
分类号 O626 [理学—有机化学]
  • 相关文献

参考文献6

  • 1王飞,林善良.硫酸头孢匹罗的合成[J].中国医药工业杂志,2005,36(8):455-456. 被引量：12
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二级参考文献12

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共引文献15

同被引文献95

引证文献7

二级引证文献13

化学试剂
2008年 第10期

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