肉毒杆菌毒素联合球囊扩张与食管支架治疗贲门失弛缓症的中长期疗效比较

A comparative study on mid-long term effect of balloon dilation combined with botulinum toxin vs reclaimable self-expanded esophageal membranous stents in the treatment of achalasia.

目的探讨肉毒杆菌毒素联合球囊扩张与可回收自膨防返流覆膜食管支架治疗贲门失弛缓症的中长期疗效。方法49例贲门失弛缓症,联合组25例:采用肉毒杆菌毒素联合球囊扩张。支架组24例:采用可回收自膨防返流覆膜食管支架,对照两组患者中长期疗效、并发症。结果联合组12个月、24个月治疗有效率分别为24/25(96.0%)、20/22(90.9%),支架组12个月、24个月治疗有效率分别为22/24(91.7%)、18/21(85.7%),联合组方法简单,并发症少,中长期疗效优于支架组。结论肉毒杆菌毒素联合球囊扩张治疗贲门失弛缓症创伤少,并发症少,中长期疗效满意,安全性高。

Objective To study the mid-long term effectiveness of balloon dilatation combined with botulinum toxin vs reclaimable self-expanded esophageal membranous stents in the treatment of achalasis. Methods Forty-nine patients with achalasia were divided into two groups： group I receiving balloon dilation combined with botulinum toxin （n = 14）; group II receiving reclaimable self-expanded esophageal membranous stents （n = 11 ）. All cases were followed up for 12 to 24 months. The clinical mid-long term effectiveness and complications were compared. Results The 12-month and 24-month effective rate in group I was 96% and 91%, and that in group II was 92% and 86%, respectively. The mid-long term curative effectiveness in group I was superior to that in group Ⅱ. Conclusion Treating achalasia with balloon dilation combined with botulinum toxin causes less trauma and fewer complications, and its mid-long term effect is satisfactory.