培哚普利和贝尼地平对高血压病患者血浆心肌营养素-1和可溶性细胞间黏附分子-1表达的影响

Effects of Perinopril and Benidipine on plasma levels of Cardiotrophin-1 and sICAM-1 in patients with essential hypertension

目的探讨高血压病患者血浆心肌营养素-1(CT-1)和血浆细胞间黏附分子-1(sICAM-1)活性的变化及培哚普利和贝尼地平对其的影响。方法应用生物素-链霉亲和素酶联免疫吸附法(BSA-ELISA)对56例高血压患者应用培哚普利和贝尼地平治疗前后及30名正常健康人,测定血浆CT-1水平和血浆sICAM-1水平。结果高血压组的血浆CT-1和血浆sICAM-1的表达明显高于正常对照组,差异有显著性(P<0.01);高血压组经培哚普利和贝尼地平治疗8周后其浓度明显下降(P<0.01)。结论高血压患者血浆CT-1水平和sICAM-1活性较正常人明显升高。培哚普利和贝尼地平在有效降压的同时能降低高血压患者血浆CT-1水平和sICAM-1浓度,以减少高血压并发症发生。

[Objective]To investigate the levels of plasma eardiotrophin-1 （CT-1）, plasma soluble intercellular adhesion molecule-1 （sICAM- 1） and the effects of Pefinopril and Benidipine treat patients with essential hyper-tension. [Methods] The Biotin-Strept-Avidin enzyme linked immunosorbent assay （BSA- -ELISA）, speetrophoto- metric assay were used to measure the plasma levels of CT-1 and sICAM- 1 in 56 patients with hypertension before and after treatment of Perinopril or Benidipine and 30 normal controls. [Results]The plasma level CT-1 and sICAM- 1 in hypertension group were significantly higher than that of normal controls （P〈0.01）. The plasma level of CT-1 and sICAM- 1 in patients with hypertensions were significantly decreased after 8 weeks of treatment of Perinopril or Benidipine （P〈0.01） . [Conclusion] Plasma levels of CT-1 and sICAM- 1 in hypertensive patients are importandy higher than normal controls. Perinopril and Benidipine not only decreased blood pressure, TC ,TG and LDL, but also decreased levels of CT-1 and sICAM- 1,decreasing the potential risk of hypertensive complication.