2型糖尿病合并代谢综合征患者血浆脂联素水平的变化及肾素血管紧张素系统对其影响

Changes of plasma adiponectin level and effect of renin angiotensin system on plasma adiponetin in type 2 diabetic patients with metabolic syndrome

目的观察2型糖尿病合并代谢综合征患者血浆脂联素水平的变化及肾素血管紧张素系统对其影响。方法测定30例2型糖尿病合并代谢综合征患者、30例2型糖尿病非代谢综合征患者和30例正常对照者血浆脂联素、血管紧张素Ⅱ水平,分析合并代谢综合征糖尿病患者血浆脂联素、血管紧张素Ⅱ水平的变化,分析两者间的相互关系。观察奎那普利治疗后糖尿病合并代谢综合征患者血浆脂联素、血管紧张素Ⅱ水平的变化。结果2型糖尿病合并代谢综合征患者血浆脂联素水平明显降低(P<0.01),血浆血管紧张素Ⅱ水平明显升高(P<0.01)。血浆脂联素水平与血管紧张素水平呈明显负相关(r=-0.409,P<0.01)。应用奎那普利治疗后患者血浆脂联素明显升高(P<0.01)、血浆血管紧张素Ⅱ水平明显降低(P<0.01)。结论2型糖尿病合并代谢综合征患者血浆脂联素水平明显降低,提示血浆脂联素与代谢综合征的发生发展可能有密切关系。血管紧张素转化酶抑制剂奎那普利对代谢综合征的治疗可能有重要意义。

[Objective] To investigate the changes of plasma adiponectin level and effect of Renin Angiotensin System on plasma level of adiponeetin in type 2 diabetic patients with metabolic syndrome. [Methods] 30 type 2 diabetic patients with metabolic syndrome, 30 type 2 diabetic patients without metabolic syndrome and 30 normal subjects were observed. Their plasma levels of adipenectin and angeotensin were measured. The changes of plasma adiponectin and angeotensin and relationship between adiponectin and angeotensin were analyzed.Tbe changes of the plasma adiponectin and angeotensin level were investigated in type 2 diabetic patients with metabolic syndrome after treatment with Quinapril Hydrochloride. [Results] The plasma levels of adiponectin were significantly decreased （P〈0.01）, the plasma levels of angeotensin were significantly increased （P〈0.01）, the levels of plasma adiponectin was negatively related to the level of plasma angeotensin in type2 diabetic patients with metabolic syndrome （r =-0.409, P〈0.01）. [Conclusion] The levels of plasma adiponectin is significantly decreased in type 2 diabetic patients with metabolic syndrome .The results suggest that the level of plasma adcponectin might be closely related to metabolic syndrome in type 2 diabetic patients .The treatment with Qunapril Hydroehloride is beneficial to metabolic syndrome.