摘要
含未甲基化CpG基序的寡脱氧核苷酸能够直接刺激B细胞等抗原递呈细胞,提高Th1产量并促进细胞因子的产生及抗原递呈细胞的成熟和活化。这使CpG寡核苷酸具有良好的免疫佐剂活性,能够促进和提高抗原特异性免疫应答。本篇着重介绍了CpG寡核苷酸作为免疫佐剂的研究进展。
Oligodeoxynucleotides （ODNs） containing unmethylated CpG motifs directly stimulate B cells and other professional antigen - presenting cells, thereby promoting the production of Th1 and proinflammatory eytokines and the maturation or activation of professional antigen - presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen -specific immune responses. This review will high- light the recent uses of CpG DNA as an immune adjuvant.
出处
《中国兽药杂志》
2008年第10期54-56,共3页
Chinese Journal of Veterinary Drug
