不同时辰针刺足少阴肾经脑功能磁共振成像对比研究

The research of brain fMRI in acupuncture of KI in different time

目的:探讨不同时辰针刺足少阴肾经后引起的脑功能变化及其各功能区在脑内定位的异同和分布规律,寻找不同时辰针刺同一经络治疗效果差异的中枢原因。方法:健康志愿者20例在足少阴肾经开穴和闭穴时配伍电针针刺太溪与复溜两穴位后进行磁共振脑功能成像实验,同时选取2个非穴位针刺点进行同样的实验作为对照。结果:足少阴肾经开穴组与闭穴组脑功能成像结果显示功能被激活信号增高和功能被抑制信号减低的脑区有不同。开穴组最大激活脑区位于双侧扣带回,最大抑制脑区位于右侧眶内侧回。闭穴组最大激活脑区位于左侧小脑,最大抑制脑区位于右侧眶内侧回。结论:脑功能磁共振成像观察到的不同时辰针刺后中枢效应的差异,不同时辰针刺非穴点后,没有这种差异。不同时辰针刺足少阴肾经后,脑功能激活信号增高脑区和信号减低抑制脑区均有差异,开穴时段内两经络激活区和抑制区的数目和范围要比闭穴时段内多和广。开穴时可以形成完整的中枢激活与反射环路,闭穴时则无法形成完整的环路。

Objective To explore the functional localization and its distributing orderliness of the central nervous system （CNS） reaction on acupuneturing the two acupoints of Kidney meridian of foot Shaoyin（KI） ,and to explore the exist and mechanism of the acupuncture of Zi-Wu-I.iu-Zhu. Methods： Twenty right-handed volunteers were selected in our studies. Every one of these 20 vohmteers were acupunctured Taixi （KI3） and Fuliu （KI7） in different time, and two false acupuncture as the compare, all acupuncture tests were performed on the right leg. The order of test was determined randomly. Results; Signal increase and de- crease were different between the ＂open＂ time and the ＂close＂ time when acupuncture the Kideny meridian of foot-Shaoyin （KI）, the most active and deactivate areas were also different. Conclusion： fMRI can delineate the different reaction of the CNS. The active, deaclivate area （signal increase and decrease） the most active and deactivate area are different when acupuncture the meridian K1 in different time. There are both same and different when acupuncture the KI. The whole active and reflect feedback routine can found when acupuncture in the ＂open＂ time, while the ＂close＂ time isn＇t.