叶下珠、干扰素治疗慢性低酶型乙型肝炎的疗效观察

Clinical Observation on chronic hepatitis B With low ALT Theated by interferon and yexiazhu

目的探索叶下珠、干扰素α-2b(IFNα-2b)不同组方治疗慢性低酶型乙型肝炎的临床治疗效果。方法用叶下珠片治疗低酶型乙型肝炎152例,3个月内ALT升高达1000U/L以上者,随机分为叶下珠继续治疗组(Ⅱa组),加用IFNα-2b组(Ⅱb组),改用IFNα-2b组(Ⅱc组),仍属低酶者设为对照组(Ⅰ组)继续应用叶下珠,Ⅰ组、Ⅱ组所有患者在相同条件下,采用不同方案继续治疗6个月。结果Ⅱa、Ⅱb、Ⅱc组均在ALT复常,HBeAg阴转,抗-HBe阳转,HBVDNA阴转方面优于Ⅰ组(P<0.05);Ⅱb、Ⅱc组明显优于Ⅰ组(P<0.05);Ⅱb、Ⅱc之间无差异(P>0.05)。结论慢性低酶型乙型肝炎患者应用叶下珠初始治疗,在ALT升高达100U/L以上,适时加用或改用IFNα-2b治疗慢性乙型肝炎可获得满意的临床疗效。

Objective To investigate the effect of Yexiazhu（YXZ） combined with interferon α -2b in the the treatment of low ALT chronic hepatitis B. Methods 152 patients with low ALT chronic hepatitis B were given YXZ. When the biochemical response （ALT 〉 100μ/L） appeared after 3months. The patients were randomly divided into four equal groups. The patients in combined treatment group were treated with YXZ and interferon α - 2b, while patients in group Ⅱ a. Ⅱ b and Ⅱ c treated only by YXZ or interferon α - 2b, respectively for 6 months. Results The liver function tests and hepatitis B virus marker were observed. The combined response （HBeAg loss HBVDNA suppression and ALT normalization） tointerferon α-2b in group Ⅱa. Ⅱb and lic show superior inefficacy with group I （P〈0.01）. lib and Ⅱc was no statistical difference （P 〉 0. 05）. Conehmions Compared with patients with chronic hepatitis B with interferon α - 2b. the clinical efficacy of interferon in the retreatment of patients with chronic hepatitis B faiure to YXZ had statistically signifi- cance and the efficacy of long trem was more satisfactory.