摘要
血管平滑肌的功能主要是通过多种机制激活Ca^2+内流使胞内Ca^2+浓度持续升高来实现的。目前的研究表明这种Ca^2^+内流与一系列瞬时感受器电位超家族成员有关,瞬时感受器电位超家族主要成员有:瞬时感受器电位C1、C3~6、V1、V2、V4、M4、M7和P2。文章概述瞬时感受器电位在血管平滑肌功能方面的作用。
出处
《中国动脉硬化杂志》
CAS
CSCD
2008年第8期659-661,672,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助项目(30670772)
福建省自然科学基金资助项目(C0620002)
参考文献30
-
1Parekh AB, Putney JW Jr. Store-operated calcium channels [J]. Physiol Rev, 2005, 85 (2): 757-810.
-
2Pedersen SF, Owsianik G, Nilius B. TRP channels: an overview [J]. Cell Calcum, 2005, 38 (3-4): 233-252.
-
3段波,徐天乐.TRP通道与信号转导[J].生物物理学报,2005,21(4):245-260. 被引量:18
-
4Ryuji I,Lars JJ,Juan S,et al.Transient receptor potential channels in cardiovascular function and disease[J].Circ Res, 2006, 99 (2): 119-131.
-
5Lin MJ, Leung GP, Zhang WM, et al. Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca^2+ channels in pulmonary arterial smooth muscle ceils: a novel mechanism of hypoxic pulmonary hypertension [J]. Circ Res, 2004, 95 (5): 496-505.
-
6Mandegar M, RemlUard CV, Yuan JX. Ion channels in pulmonary arterial hypertension [J]. Prog Cardiovasc Dis, 2002, 45 (2): 81-114.
-
7Moneer Z, Pino I, Emily JA, et al. Different phospholipase C-coupled receptors differentially regulate capacitative and non-capacitatlve Ca^2 + entry in A7r5 cells [J]. Biochem J, 2005, 389 (3) : 821- 829.
-
8Worley PF, Zeng WZ, Huang GN, et al. TRPC channels as STIM1-regulated store-operated channels [J]. Cell Calcium, 2007, 42 (2): 205-211.
-
9Yang XR,Lin MJ,McIntosh LS,et al.Functional expression of transient receptor potential melastatin-and vanilloid-related channels in pulmonary arterial and aortic smooth muscle[J].Am J Physiol Lung Cell Mol Physiol.2006, 290 (6) : 1 267-276.
-
10Beech DJ, Xu SZ, McHugh D, et al. TRPCI : store-operated cationic channel subunit [J]. Cell Calcum 2003, 33 (5-6) : 433- 440.
二级参考文献86
-
1Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E,Birnbaumer L. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca^2+ entry. Cell, 1996,85:661-671.
-
2Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN,Spencer KS, Andahazy M, Story GM, Patapoutian A .Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science, 2005,307:1468-1472.
-
3Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M. Heat-evoked activation of the ion channel, TRPV4.J Neurosci, 2002,22:6408-6414.
-
4Viana F, de la Pena E, Belmonte C. Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat Neurosci, 2002,5:254-260.
-
5Viswanath V, Story GM, Peier AM, Petrus MJ, Lee VM,Hwang SW, Patapoutian A, Jegla T. Opposite thermosensor in fruitfly and mouse. Nature, 2003,423:822-823.
-
6Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J,Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D.Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 2000,288:306-313.
-
7Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol, 2003,140:790-801.
-
8Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY,Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffrnan NIP, Rehm HL,Tamasauskas D, Zhang DS. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.Nature, 2004,432:723-730.
-
9Nagata K, Duggan A, Kumar G, Garcia-Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci, 2005,25:4052-4061.
-
10Zhang y, Hoon MA, Chandrashekar J, Mueller KL, Cook B,Wu D, Zuker CS, Ryba NJ. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell, 2003,112:293-301.
共引文献23
-
1徐超,江洪,姚园,王腾.曲尼司特抑制大鼠胸主动脉球囊损伤后再狭窄[J].心脏杂志,2006,18(3):289-292.
-
2陈浮,苏纪平.耳蜗血管纹内皮细胞的机械敏感性离子通道[J].新乡医学院学报,2007,24(2):207-210. 被引量:1
-
3王瑞幸,方秋娟,林默君.医学研究生心血管生理学实验教学的几点体会[J].山西医科大学学报(基础医学教育版),2007,9(2):174-176. 被引量:1
-
4范青锋,邢燕,刘淑芳,张涵,丁洁.瞬时受体电位阳离子通道蛋白6在肾脏的表达[J].实用儿科临床杂志,2007,22(17):1293-1295. 被引量:3
-
5杨征,邱敏,吴芹,李利生,黄燮南.家兔动脉血管平滑肌细胞培养方法的改进[J].中国药理学通报,2008,24(5):696-699. 被引量:12
-
6王勇,桂耀庭.钙离子通道在精子运动中的作用及其临床意义[J].中华男科学杂志,2008,14(9):832-836. 被引量:10
-
7郑向红,刘晓如,林默君.大鼠肺动脉平滑肌细胞培养及对不同类型激动剂刺激产生的反应[J].海峡药学,2008,20(12):20-22.
-
8刘双,王克威.TRP通道蛋白异源组装的研究进展[J].生物物理学报,2009,25(1):15-21.
-
9孙维洋,李峰,欧阳兵,王振国.瞬时受体电位通道与中药药性现代研究[J].中国中医药信息杂志,2009,16(8):8-9. 被引量:5
-
10韩琴.TRP通道参与温度感觉的分子机制[J].成都医学院学报,2009,4(3):220-224. 被引量:4
同被引文献28
-
1Lin MJ, Leung GP, Zhang WM, et al. Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca^2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension[J].Circ Res, 2004, 95 (5) : 496 - 505.
-
2Várnai P,Hunyady L,Balla T.STIM and Orai:the long-awaited constituents of store-operated calcium entry[J].Trends Pharmacol Sci,2009,30(3):118-128.
-
3Brandman O,Liou J,Park WS,et al.STIM2 is a feedbackregulator that stabilizes basal cytosolic and endoplasmic re-ticulum Ca2+levels[J].Cell,2007,131(7):1 327-339.
-
4Deng X,Wang Y,Zhou Y,et al.STIM and Orai:dynam-ic intermembrane coupling to control cellular calcium sig-nals[J].J Biol Chem,2009,284(34):22 501-505.
-
5Hogan PG,Lewis RS,Rao A.Molecular basis of calciumsignaling in lymphocytes:STIM and ORAI[J].Annu RevImmunol,2010,28:491-533.
-
6Smyth JT,Hwang SY,Tomita T,et al.Activation and reg-ulation of store-operated calcium entry[J].J Cell MolMed,2010,14(10):2 337-349.
-
7Stathopulos PB,Zheng L,Li GY,et al.Structural andmechanistic insights into STIM1-mediated initiation of store-operated calcium entry[J].Cell,2008,135(1):110-122.
-
8Oh-Hora M,Yamashita M,Hogan PG,et al.Dual func-tions for the endoplasmic reticulum calcium sensors STIM1and STIM2 in T cell activation and tolerance[J].Nat Im-munol,2008,9(4):432-443.
-
9Ji W,Xu P,Li Z,et al.Functional stoichiometry of the u-nitary calcium-release-activated calcium channel[J].ProcNatl Acad Sci USA,2008,105(36):13 668-673.
-
10Muik M,Frischauf I,Derler I,et al.Dynamic coupling ofthe putative coiled-coil domain of ORAI1 with STIM1 medi-ates ORAI1 channel activation[J].J Biol Chem,2008,283(12):8 014-022.
引证文献3
-
1郑向红,刘晓如,林默君.大鼠肺动脉平滑肌细胞培养及对不同类型激动剂刺激产生的反应[J].海峡药学,2008,20(12):20-22.
-
2刘青,林默君.钙池操纵性钙通道的激活信号分子与肺动脉高压[J].中国动脉硬化杂志,2012,20(3):273-277. 被引量:4
-
3李霜,张政,王觅.TRPM7通道激酶研究进展[J].中南医学科学杂志,2018,46(4):437-440. 被引量:4
二级引证文献8
-
1林达岑,林默君,周瑞祥.瞬时感受器电位通道在肿瘤增殖与迁移中的作用[J].中国药理学通报,2016,32(11):1500-1505. 被引量:2
-
2王腊梅,胡清华,钟华,唐娜,孙志萍,何芳.TRPC1/STIM1复合体调节人脐静脉内皮细胞钙池操纵性钙通道和受体操纵性钙通道介导的钙内流和NO生成[J].中国动脉硬化杂志,2017,25(8):764-772. 被引量:1
-
3王腊梅,钟华,唐娜,庞丽娟,张春军,何芳.钙离子感受蛋白STIM1与Orai1在钙敏感受体介导钙内流及NO生成中的相互作用[J].中国病理生理杂志,2017,33(10):1773-1780. 被引量:1
-
4王腊梅,钟华,唐娜,庞丽娟,孙志萍,何芳.钙离子信号蛋白TRPC1及Orai1参与了HUVEC经SOC和ROC介导的钙内流和NO生成[J].中国动脉硬化杂志,2017,25(12):1189-1195. 被引量:3
-
5齐振平,李俊林,张秀玲,潘艳飞,付丹丹.血清肿瘤标志物联合多层螺旋CT和核磁共振对胆管癌的诊断价值及其与组织侵袭分子的关系分析[J].现代生物医学进展,2019,19(20):3951-3954. 被引量:15
-
6李爱迪,聂敏海,左东川,饶勇,曾锦.TRPM7通道对人口腔颊黏膜成纤维细胞增殖和迁移的影响[J].西南医科大学学报,2020,43(2):135-139. 被引量:1
-
7高家乐,刘建勋.脑缺血疾病相关离子通道研究进展及中药防治[J].中国中药杂志,2020,45(21):5110-5116. 被引量:7
-
8匡泓俊,杨腊媛,袁楠,袁杨阳,杨钰涛,钟峰.基于调控外泌体释放的电针对慢传输型便秘大鼠结肠组织TRPM7-PI3K/Akt通路的影响[J].中国中医药信息杂志,2022,29(12):98-103. 被引量:1
-
1杜新颖,王祖智.环核苷酸对血管平滑肌功能的调节[J].武汉医学杂志,1991,15(3):186-187.
-
2谭明,钱雪冶.影响内耳毛细胞胞内Ca_(2+)浓度的几种因素[J].上海医学,1996,19(12):736-737.
-
3杨军,汪吉宝,韦顺会.三种神经活性物质对离体豚鼠耳蜗外毛细胞内游离钙浓度的影响[J].中华耳鼻咽喉科杂志,1998,33(5):279-281. 被引量:5
-
4董莉.小剂量阿司匹林对高血压内皮及血管平滑肌细胞功能的影响[J].中国社区医师(医学专业),2010,12(24):159-159.
-
5林默君,关永源,贺华.Janu2亚型酪氨酸激酶在环匹阿尼酸触发的大鼠主动脉血管环收缩效应中的作用[J].福建医科大学学报,2001,35(4):307-310. 被引量:1
-
6张海宁,丘钦英,关永源.反义ClC-3寡核苷酸对thapsigargin触发的Ca^2+运动的影响[J].中山大学学报(医学科学版),2008,29(5):526-530.
-
7陈彦静,马建伟,王德宝,张静.肠淋巴液对大鼠心室肌细胞内动作电位的影响[J].张家口医学院学报,1998,15(2):9-10.
-
8刘永全.整合素与信号转导[J].国外医学(免疫学分册),2000,23(1):33-37. 被引量:10
-
9刘振伟,王福庄,要航,丁爱石,黄燕华.用Fura-2测定缺氧时海马细胞内游离钙离子浓度的变化[J].细胞生物学杂志,1994,16(3):141-143. 被引量:6
-
10张晓峰,丰美福,吴才宏,周培爱.粒细胞巨噬细胞集落刺激因子诱导的巨噬细胞外向K^+电流的特性[J].生理学报,1998,50(2):153-162. 被引量:1