ZT胶碘油混合物选择性门静脉栓塞的实验研究

Experimental study of selective portal vein embolization with the mixture of ZT glue and lipiodol

目的探讨ZT胶碘油混合物行兔选择性门静脉栓塞（SPVE）的可行性。方法新西兰白兔16只，随机分为2组，A组为ZT胶碘油（1：2）混合物组，B组为碘油组，数字减影血管造影下对门静脉左支进行SPVE，观察各组栓塞材料的分布特点、术后30d肝脏组织病理学和右肝重／全肝重的变化。结果A组呈永久性栓塞，B组出现再通；栓塞侧肝叶萎缩、纤维化，非栓塞侧肝叶代偿性增生肥大；右肝重／全肝重A组为（69．41±5．10）％，B组为（39．00±6．58）％，2组比较，差异有统计学意义（P〈0．05）。结论ZT胶碘油（1：2）混合物进行SPVE，呈永久性栓塞．能诱导被栓塞肝叶萎缩未栓塞肝叶代偿性增生肥大。

Objective To evaluate the feasibility of Selective Portal Vein Embolization （SPVE） in Tabbits with the mixture of ZT glue and Lipiodol. Methods Sixteen white New Zealand rabbits were randomly divided into 2 groups ： Group A, ZT glue ： Lipiodol （ 1 ： 2） mixture and Group B Lipiodol group. SPVE of left branch was performed in each group under digit.al subtraction angiography. The distribution feature of the embolic agents and the histopathology of liver in each group were observed. The weight ratio of the right lobe to the whole liver at the 30th day after SPVE were recorded and analyzed. Results Permanent embolization were occurred in group A. Recanalization was appeared in group B. Atrophy of the embolized lobes and compensatory hypertrophy of none-embolized lobes was observed. The weight ratio of the right lobe to the whole liver was 69.41±5.10% in group A. There was statistical difference between these two groups （ P 〈 0. 05 ）. Conclusion There were permanent embolization after SPVE with the mixture of ZT glue and lipiodol. SPVE induced atrophy of the embolized lobes of liver and compensatory hypertrophy of none-embolized lobes.