糖尿病大鼠周围神经功能及结构的改变及意义

Changes and meaning of function and structure of diabetic rats＇ peripheral nerve

目的了解糖尿病状态下周围神经损伤的发展过程。方法链脲菌素诱导糖尿病，分别在2、4、6、8、12周，通过神经传导速度、热痛阈值、坐骨神经结构改变和腓肠神经定量分析，动态观察糖尿病大鼠周围神经的功能和结构变化特点。结果糖尿病大鼠2周即可出现神经传导速度减慢、痛觉闽值减低等功能改变，4周出现超微结构改变，并随病程延长逐渐加重。结论实验性糖尿病大鼠早期即出现神经病变，且功能改变先于结构病变。

Objective The aim of this study is to understand the development of peripheral nerve injury on diabetes mellitus. Methods Diabetes was induced by STZ. We determined nerve conduction velocity, thermal pain threshold, morphology changes of sciatic nerve and quantitative analysis of sural nerve of diabetic model group and normal control group after 2 weeks ,4 weeks ,6 weeks ,8 weeks, 12 weeks respectively, and observed dynamically functional and morphologic changes of peripheral nerve of diabetic rats. Results After 2 weeks, diabetic rats showed that motor and sensory nerve conduction velocities slowed down and thermal pain threshold decreased. After 4 weeks, changes of pathology of sciatic nerve were observed. With the duration extending, the damages of nerve were aggravated gradually. Condusions Neuropathy appeared in earlier stage on experimental diabetic rats and functional changes were preceded to morphologic changes.