9-(E)-红霉素肟的合成工艺改进

Improved synthesis of erythromycin 9-(E)-oxime

以硫氰酸红霉素为原料,经过肟化和碱化反应制得合成第二代大环内酯类抗生素阿奇霉素、罗红霉素和克拉霉素的中间体9-(E)-红霉素肟,总收率为95.8%。目标化合物结构经MS和1H-NMR谱确证。

Erythromycin 9-（E ）-oxime, the key intermediate for the synthesis of the second generation macrolide antibiotics including azithromycin, roxithromycin and clarithromycin, was synthesized from erythromycin thiocyanate by oximation and alkalinization with an overall yield of 95.8 %. The structure of the erythromycin 9-（E）-oxime was identified by MS and ^1H-NMR.