摘要
结合纳米羟基磷灰石(n-HA)和聚合物的优点,采用溶液共混相分离制备出聚己内酯(PCL)-壳聚糖(CS)多孔支架材料,并采用离心注浆填充新方法对支架材料进行增强,制备复合多孔支架材料。用扫描电子显微镜、红外光谱、元素分析、孔隙率和抗压强度对材料进行了表征。结果表明复合材料具有良好的界面结合;孔隙率分析表明材料具有60%~80%的孔隙率,符合骨组织工程对支架材料的要求;力学性能测试表明材料的压缩强度得到大幅度提高。
Combining the advantages of nano-hydroxyapatite(HA) and polymers, polycaprolactone (PCL)- chitosan(CS) porous scaffold was prepared by solution blend and phase separation method. In order to improve the mechanical strength of the scaffold, the scaffold was then enhanced by infilling with n-HA-polyvinyl-alcohol (PVA) composite slurry to prepare n-HA/PCL-CS composite porous scaffold through a novel method--centrifugal slipcasting technique. The characteristic of this technique and that scaffold were discussed through scanning electron mierographs, fourier transform infrared spectroscopy, elemental analysis, porosity and compressive strength. The results show that the scaffold with 60%- 80% porosity has a good interface bonding. The aperture of the scaffold is accordance with the requirement of bone tissue engineering, relative high porosity and owning a adequate pore size which could satisfy the requirement to bone repair substitutes. The compressive strength of the scaffold has been improved significantly.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2008年第10期155-158,共4页
Polymer Materials Science & Engineering
基金
福建省科技厅重点资助项目(2006I0015)
福建师范大学本科生课外科技计划资助项目(BKL2006-23)
关键词
羟基磷灰石
聚己内酯
壳聚糖
聚乙烯醇
多孔支架
hydroxyapatite
polycaprolactone
chitosan
polyvinyl alcohol
porous scaffold