期刊文献+

睫状神经营养因子治疗代谢综合征的研究进展 被引量:1

Research progress of ciliary neurotrophic factor in metabolic syndrome
下载PDF
导出
摘要 本文总结了睫状神经营养因子(CNTF)的生物学特性及其对代谢综合征的影响,分析了其如何通过调节血脂、促进能量代谢、保护神经等途径改善代谢综合征的机制,并探讨了CNTF应用于治疗代谢综合征的前景。 The biological characteristics of ciliary neurotrophic factor (CNTF) and its effect on metabolic syndrome (MS) are summaried in this paper. The action mechanism of CNTF in blood-lipid regulation, promoting energy metabolism, protecting nerve is analyzed, and the prospect and some problems of CNTF used in the treatment of MS are also discussed.
出处 《国际药学研究杂志》 CAS 2008年第5期346-348,共3页 Journal of International Pharmaceutical Research
基金 国家自然科学基金资助项目(No.30672773)
关键词 睫状神经营养因子 代谢综合征 能量代谢 瘦素 糖尿病 ciliary neurotrophic factor metabolic syndrome energy metabolism l eptin diabetes meUitus
  • 相关文献

参考文献17

  • 1[1]Adiels M,Taskinen MR,Borén J.Fatty liver,insulin resistance,and dyslipidemia[J].Curr Diab Rep,2008,8(1):60 -64.
  • 2[2]Towfighi A,Ovbiagele B.Metabolic syndrome and stroke[J].Curt Diab Rep,2008,8(1):37 -41.
  • 3[3]Blüher S,Mosehns S,Bullen J,et al.Ciliary neurotrophic factor Ax15 alters energy homeostasis,decreases body weight,and improves metabolic control in diet-induced obese and UCPI-DTA mice[J].Diabetes,2004,53(11):2787 -2796.
  • 4[4]Kelly JF,Elias CF,Lee CE,et al.Ciliary neurotropbic factor and leptin induce distinct patterns of immediate early gone expression in the brain[J].Diabetes,2004,53(4):911 -920.
  • 5[5]Aylwin S,Al-Zaman Y.Emerging concepts in the medical and surgical treatment of obesity[J].Front Horm Res,2008,36:229-259.
  • 6[6]Qi H,Chuang EY,Yoon KC,et al.Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions[J].Mol Vis,2007,16(13):1934-1941.
  • 7[7]Liu QS,Wang QJ,Du GH,et al.Recombinant human ciliary neurotrophic factor reduces weight partly by regulating nuclear respiratory factor 1 and mitochondrial transcription factor A[J].Eur J Phannacol,2007,563(1 -3):77 -82.
  • 8[8]Liu QS,Gao M,Zhu SY,et al.The novel mechanism of recombinant human ciliary neurotrophic factor on the anti-diabetes activity[J].Basic Clin Pharmacol Toxicol,2007,101(2):78-84.
  • 9[9]Febbraio MA.Gp130 reoeptor ligands as potential therapeutic targets for obesity[J].J Clin Invest,2007,117 (4):841 -849.
  • 10[10]Schafer KH,Hagl CI,Rauch U.Differentiation of neurospheres from the enteric nervous system[J].Pediatr Surg Int,2003,19(5):340 -344.

二级参考文献19

  • 1马红萍,朱毅芳,邵政一.神经再生素对糖尿病大鼠周围神经病变的保护作用[J].中国临床康复,2005,9(29):87-89. 被引量:3
  • 2LAMBERT P D, ANDRSON K D, SLEEMAN M W,et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body weight gain, even in leptin-resistant obesity [ J ]. Proc Natl Acad Sci USA, 2001,98 (8) :4652-4657.
  • 3LIU Q S, WANG Q J, DUG H, et al. Recombinant human ciliary neurotrophic factor reduces weight partly by regulating nuclear respiratory factor 1 and mitochondrial transcription factor A [ J ]. Eur J Pharmacol,2007,563 ( 1-3 ) :77-82.
  • 4WATT J A, BONE S, PRESSLER M, et al. Ciliary neurotrophic factor is expressed in the magnocellular neurosecretory system of the rat in vivo: Evidence for injury- and activity-induced up-regulation[J]. Exp Neurol, 2006,197( 1 ) :206-214.
  • 5MASSICOTTE C, BARBER D S, JORTNER B S, et al. Nerve conduction and ATP concentrations in sciatic-tibial and medial plantar nerves of hens given phenyl saligenin phosphate [ J ]. Neurotoxicology, 2001,22( 1 ) :91-98.
  • 6HSIEH H L,SCHAFER B W, SASAKI N, et al. Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays[ J ]. Biochem Biophys Res Commun, 2003,307 ( 2 ) : 375 -381.
  • 7MIOTKE J A, MACLENNAN A J, MEYER R L. Immunohistochemical localization of CNTFRalpha in adult mouse retina and optic nerve following intraorbital nerve crush: evidence for the axonal loss of atrophic factor receptor after injury[J]. J Comp Neurol, 2007,500(2) :384-400.
  • 8LIU Q S, GAO M, ZHU S Y,et al. The novel mechanism of recombinant human ciliary neurotrophic factor on the anti-diabetes activity[ J ]. Basic Clin Pharmacol Toxicol, 2007,101 ( 2 ) : 78- 84.
  • 9NICHOLLS K, Diabetic nephropathy how might we prevent, retard, or cope with it[J], Aust Faro Pbysician, 2005,34( 11 ) : 933-936.
  • 10Arakawa Y,Sendtner M,Thoenen H.Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture:comparison with other neurotrophic factors and cytokines[J].J Neurosci,1990,10(11):3507

共引文献6

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部