摘要
作为医学研究的重点课题,基因转移技术可以分为物理学法、化学法和生物学法三大类。本文阐明其中现有技术方法的原理,比较其特点及局限,并对其前景进行展望。
出处
《西部医学》
2008年第6期1288-1290,共3页
Medical Journal of West China
基金
第三军医大学校管基金资助项目(2006)
重庆市自然科学基金面上项目资助(CSTC
2006BB5063)
国家自然科学基金资助(No:39970269)
参考文献4
-
1邓一静,倪兵,姜曼,杨玓,李凡,吴玉章.Pokemon基因siRNA逆转录病毒重组表达质粒的构建及鉴定[J].免疫学杂志,2006,22(2):203-205. 被引量：11
-
2DongpingGUO,XiaoyuLI,PingSUN,ZhiguangWANG,XiuyingCHEN,QiCHEN,LemingFAN,BinZHANG,LizhengSHAO,XiaorongLI.Ultrasound/Microbubble Enhances Foreign Gene Expression in ECV304 Cells and Murine Myocardium[J].Acta Biochimica et Biophysica Sinica,2004,36(12):824-831. 被引量：12
-
3Siddhartha S. Ghosh,P. Gopinath,A. Ramesh. Adenoviral vectors[J] 2006,Applied Biochemistry and Biotechnology(1):9～29
-
4Peter Chrenek,Dusan Vasicek,Alexander V. Makarevich,Rastislav Jurcik,Karin Suvegova,Vladimir Parkanyi,Miroslav Bauer,Jan Rafay,Angelika Batorova,Rekha K. Paleyanda. Increased transgene integration efficiency upon microinjection of DNA into both pronuclei of rabbit embryos[J] 2005,Transgenic Research(4):417～428
二级参考文献29
-
1杨文博,孔佩艳,刘红,彭贤贵,常城,魏立,曾东风,刘林,陈幸华,王庆余.RNA干扰抑制基质细胞衍生因子-1基因的表达[J].免疫学杂志,2005,21(2):111-113. 被引量：1
-
2Maeda T, Hobbs RM, Merghoub T, et al. Role of the protooncogene Pokemon in cellular transformation and ARF repression [J]. Nature,2005,433 (7 023):278 - 285.
-
3Liu CJ, Prazak L, Fajardo M, et al. Leukemia/lymphomarelated factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis [J]. J Biol Chem, 2004, 279(45): 47 081-47 091.
-
4Lee DK, Suh D, Edenberg H J, et al. POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1 [J]. J Biol Chem, 2002, 277(30):26 761 - 26 768.
-
5Laudes M, Christodoulides C, Sewter C, et al. Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis [ J ]. J Biol Chem, 2004, 279 ( 12 ):11 711-11 718.
-
6Pendergrast PS, Wang C, Hernandez N, et al. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb--containing nuclear speckles [J]. Mol Biol Cell, 2002, 13(3) :915 - 929.
-
7HannonGJ. RNAinterference [ J ]. Nature ,2002,418(6 894):244 - 251.
-
8Stevenson M. Therapeutic potential of RNA interference[J].N Engl J Med, 2004, 351(17):1 772- 1 777.
-
9Oligino TJ, Yao QP, Ghivizzani SC, et al. Vector systems for gene transfer to joints [J]. Clin Orthop, 2000, 379 (Supp1): S17 - S30.
-
10Tachibana K, Uchida T, Ogawa K, Yamashita N. Tamura K. Induction of cell-membrane porosity by ultrasound. Lancet. 1999, 353:1409-1411
共引文献21
-
1吴阳,张水军,丁月超.Pokemon基因在原发性肝癌组织中的表达及意义[J].山东医药,2008,48(5):92-93. 被引量：4
-
2王建华,史京萍,沈历宗,丁强,卢春,林红军,吴文溪.超声介导SonoVue微泡破裂促进报告基因在肝脏中表达的实验研究[J].南京医科大学学报（自然科学版）,2006,26(4):249-252. 被引量：3
-
3陈云超,张青萍,LIANG Hai-dong,朱蔚,张超,Martin JK Blomley,LU Qi-long.超声和微泡造影剂介导细胞基因转染的实验研究[J].中华超声影像学杂志,2006,15(11):864-868. 被引量：22
-
4李剑峰,白玉贤.Pokemon基因研究进展[J].实用肿瘤学杂志,2007,21(1):98-100. 被引量：5
-
5陈琦,曹慧,高哓飞,张海燕,王芬,李厚达.人B-CAM/Lu基因逆转录病毒载体的构建及其在L929细胞中的表达[J].免疫学杂志,2007,23(4):445-448.
-
6陈云超,黄道中,李开艳,王志辉,洪恺,王芬,张青萍.Ultrasound and Microbubbles: Their Functions in Gene Transfer In Vitro[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2007,27(4):479-482.
-
7任建丽,王志刚.超声微泡造影剂在心血管疾病基因治疗中的应用[J].中国医学影像技术,2007,23(8):1257-1259. 被引量：6
-
8高伟,隋军,李晓江,任艳鑫.Pokemon在肿瘤中的研究进展[J].中国医学文摘（肿瘤学）,2007,21(4):340-342. 被引量：2
-
9林婵,王力,边六交.维甲酸受体β基因RNAi表达质粒的构建及其对A549细胞增殖和分化的影响[J].生物技术通讯,2008,19(3):344-346. 被引量：1
-
10夏仁品,卢实春,武聚山,李宁,郑静.RNA干扰抑制小鼠OX40基因表达的实验研究[J].免疫学杂志,2008,24(6):674-677.
同被引文献23
-
1周骏宇.品牌的进化[J].企业管理,2006(11):24-25. 被引量：6
-
2杨金勇,黄克正,尚勇,李长江.产品基因研究综述[J].机械设计,2007,24(4):1-4. 被引量：22
-
3Pouton CW,Seymour LW.Key issues in non-viral gene delivery[J].Adv Drug Deliv Rev,2001,46(2):187.
-
4Jarver P,Lange I U.The use of cell-penetrating peptides as a tool for gene regulation[J].Drug Discov Today,2004,9(9):395-402.
-
5Tsai JT,Furstoss KJ,Michnick T,et al.Quantitative physical characterization of lipid-polycation-DNA lipopolyplexes[J].Biotechnol Appl Biochem,2002,36(1):13.
-
6Li S,Rizzo MA,Bhattacharya S,et al.Characterization of cationic lipid-protamine-DNA(LPD)complexes for intravenous gene delivery[J].Gene Therapy,1998,5(8):930.
-
7Arangoa MA,Düzgünes N,Ilarduya CT.Increased receptor-mediated gene delivery to the liver by protamine-enhanced-asialofetuin-lipoplexes[J].Gene Therapy,2003,10(1):5.
-
8Schwarze SR,Ho A,Vecero-Akbani A,et al.In vivo protein transduction:delivery of a biologically active protein into the mouse[J].Science,1999,285(5433):1569-1572.
-
9Matsui H,Tomizawa K,Matsushita M.Protein transduction by poly-arginine[J].Nippon Yakurigaku Zasshi,2003,121(6):435-439.
-
10Kalderon D,Richardson W D,Markham A F,et al.Sequence requirements for nuclear location of simian virus 40 large-Tantigen[J].Nature,1984,311:33-38.
-
1张中庸,周礼贤.我市牧业生物技术现状及发展刍议[J].天津畜牧兽医,1994,11(3):1-2.
-
2马兰萍.转基因食品现状及发展展望[J].中学生物学,2007,23(1):5-6. 被引量：1
-
3顾凡及,齐翔林,郭爱克,汪云九.日本脑科学的现状及发展战略[J].生物物理学报,1999,15(1):13-13. 被引量：3
-
4杨其光.生物技术产业现状及发展对策[J].安徽农学通报,1998,4(4):7-8.
-
5李宝璋.生物化工领域的现状及发展[J].西部高新科技,1996(3):43-43.
-
6陈兆平.海南省实验动物工作现状及发展对策初探[J].实验动物科学与管理,1996,13(1):43-45.
-
7汪行舟,安立龙.海星资源的开发现状及发展动态[J].饲料研究,2008,31(3):64-66. 被引量：11
-
8范代娣,李宝璋.植物细胞大规模培养现状及发展[J].高技术通讯,1993,3(7):38-40.
-
9上官周平.植物生理生态学研究现状及发展[J].世界农业,1997(2):23-25.
-
10卢昕.生物传感器──国内研究现状及发展动向[J].广西师范大学学报（自然科学版）,1995,13(3):61-65. 被引量：3
