代谢综合征对冠心病患者冠脉病变程度的预测价值

Prediction effect of metabolism syndrome on the severity of coronary artery stenosis in elderly patients with coronary artery disease

目的:研究合并代谢综合征(MS)的老年冠心病(CAD)患者冠脉病变的严重程度,分析MS预测CAD冠脉病变程度的特异性和敏感性。方法:连续入选151例经冠状动脉造影检查明确诊断为CAD的老年患者(≥60岁),评估冠脉病变情况,根据是否存在MS进行分组,分析MS对冠脉病变程度的影响。结果:151例CAD患者中合并MS者64例。相对于非MS组,MS组3支病变(狭窄≥50%)显著增多(60.9%∶32.2%,P=0.000)。2支以上严重狭窄病变(狭窄≥75%)显著增多(64.1%∶39%,P=0.002)。MS在CAD患者中预测3支病变(≥50%)的敏感性为58.2%,特异性为70.2%,预测2支以上严重狭窄病变(≥75%)的敏感性为64.1%,特异性为60.9%。结论:合并MS的冠心病患者冠脉狭窄严重,病变广泛。MS可以作为预测严重冠脉病变的指标。

Objective： To study the prediction effect of metabolism syndrome on the severity of coronary artery stenosis in the elderly patients with coronary artery disease （CAD）. Methods： A total of 151 elder patients with angiography proven CAD were grouped according to the presence with or without MS （64 cases, 87cases）, Results： Compared with non MS patients the CAD patients had more 3-- vessel lesion （the severity of stenosis≥50% ,60.9% ： 32.2% ,P= 0. 000） and ≥2-- vessel lesion of more severity of stenosis （≥ 75 %, 64.1% ： 39 %, P = 0. 002） in CAD patients with MS. Sensitivity and specificity of MS diagnosing 3--vessel lesion （the severity of stenosis ≥50%） of coronary artery were 58.2 % and 70.2 % respectively. MS was a predictor of ≥2--vessel lesion and more significant stenosis （the severity of stenosis≥75 % ） of the coronary artery with sensitivity of 64.1%, specificity of 60.9 %. Conclusion： Coronary artery stenosis is much more severe in CAD patients with MS. MS is an additive predictor of coronary artery disease.