冠心病患者颈动脉斑块与碱性成纤维细胞生长因子的关系

Relationship between basic fibroblast growth factor and plaque of carotid artery atheroscleorsis in aged patients with coronary artery disease

目的:探讨老年冠心病患者颈动脉粥样硬化斑块与碱性成纤维细胞生长因子(bFGF)的关系和临床意义。方法:bFGF测定采用酶联免疫吸附测定(ELISA)法。结果:bFGF含量:正常对照组(30例)为(247.82±9.45)μg/ml,硬斑组(89例)为(280.74±12.70)μg/ml,较正常对照组显著增加(P<0.05);软斑组(39例)为(317.16±13.42)μg/ml,混合斑块组(25例)为(340.84±11.76μg/ml),较正常对照组均显著增加(P<0.05);颈动脉粥样硬化斑块Ⅰ型(38例)为(250.31±11.60)μg/ml,Ⅱ型(80例)为(270.11±13.12)μg/ml,Ⅲ型(10例)为(350.12±14.30)μg/ml,Ⅱ、Ⅲ型的bFGF水平较正常对照组非常显著增加(P均<0.01)。结论:bFGF水平反映老年冠心病的颈动脉粥样硬化程度,有一定参考价值。

Objective： To evaluate the relationship between basic fibroblast growth factor and carotid artery atheroscleorsis in the aged patients with coronary artery disease. Methods： Examination of common carotid artery （CCA） and internal carotid artery （ICA）, bifurcations （CBS） was performed by B-mode Doppler supersonic; the bFGF was measured by the enzyme linked immunosorbent assay （ELISA） methods. Results： The content of bFGF in the soft plaques group （39 cases） was （317. 16±13.42） μg/ml, hard plaques group （89 cases） was （280.74±12.70） μg/ ml, mixed plaque group （25 cases） was （340.84± 11.76） μg/ml; All their levels significantly increased compared with control group 1-30 cases, （247.82±9.45） μg/ml, P〈0. 05-0.01]. Conclusion： Levels of bFGF may be an important factor during the development artery atheroscleorsis, providing important role in distinguishing the degree of artery atheroscleorsis disease.