阿托伐他汀并厄贝沙坦对单纯收缩期高血压患者脉压的影响

Effects of atorvastatin combined with irbesartan on pulse pressure in old patients with isolated systolic hypertension

目的:观察阿托伐他汀和厄贝沙坦片联合用药对老年单纯收缩期高血压(ISH)患者脉压(PP)的影响。方法:64例老年ISH患者被随机分为两组,对照组32例用厄贝沙坦(150mg/d),治疗组32例用厄贝沙坦(150mg/d)加阿托伐他汀(10mg/d),观察12周,每2周随访血压1次并记录。结果:在治疗12周时,对照组PP从治疗前(74.67±7.77)mmHg降至(67.37±5.53)mmHg;治疗组PP从治疗前(75.06±6.96)mmHg降至(59.75±5.92)mmHg。治疗后两组PP的差异有显著性(t=5.255,P<0.01)。结论:阿托伐他汀和厄贝沙坦联合用药有助于改善老年ISH患者的PP。

Objective： To observe the effects of atorvastatin combined with irbesartan on pulse pressure （PP） in old patients with isolated systolic hypertension （ISH）. Methods： Sixty four old patients with normal level of cholesterol were divided into the two groups. Irbesartan of 150 mg/d dosage was taken by 32 subjects in control group. Thirty two cases in treatment group were administered orally with irbesartan of 150 mg/d dose and 10 mg/d atorvastatin. Blood pressure was followed-up and recorded every two weeks for 12 weeks. Results： After treatment the PP decreased from pretreatment （74.67±7.77） mmHg to （67.37 ± 5.53） mmHg in control group. Atorvastatin combined with irbesartan resulted in a significant improvement of PP from pretreatment （75.06± 6.96） mmHg to （59.75 ±5.92） mmHg. There was a significant difference between two groups for PP after treatment （P〈0.01）. Conclusion： A combination treatment with atorvastatin and irbesartan is helpful to the PP improvementin in old patients with ISH.