微量元素与卵巢癌的关系及临床应用

THE CORRELATION OF TRACE ELEMENTS WITH OVARIAN CANCER AND CLINICAL APPLICATION VALUE

采用ＰＥ公司３０３０原子吸收分光光度计，对５４例卵巢癌、２０例卵巢良性疾病患者进行血清、头发、组织中铜、锌、铁、锰、钙水平和铜／锌比值的测定。并以５０例健康成年女性为对照，测定结果进行单因素分析，卵巢癌患者血清、头发和组织中的铜、锰水平及铜／锌比值明显高于良性疾病组和正常对照组，而锌、铁、钙明显低于正常对照组，差异显著，分别（Ｐ＜０．０１～０．００１）。非条件Ｌｏｇｉｓｔｉｃ回归多因素分析表明有：卵巢癌患者血清铜／锌比值的比数比为５９．８０，９５％ＣＩ（１２．７３～２８０．９２）。提示：铜／锌比可能是卵巢癌发病危险因素。结果还表明，以健康对照组铜／锌比值１．１０为界值，对卵巢癌诊断阳性率为８１．４８％。提示铜／锌比值对卵巢癌的诊断，良恶性的鉴别有重要价值。

The serum,hair and tissue levels of zinc (Zn),copper (Cu),iron (Fe),manganese (Mn),calcium (Ca) and Cu/Zn ratio were determined by atomic absorption spectrophotometry in 54 patients with ovarian cancer,20 patients with benign diseases and 50 healthy normal controls.The result showed that serum,hair and tissue levels of Cu,Mn,and Cu/Zn ratio were significantly higher,while the serum,hair levels of Zn,Ca and Fe were signifcantly lower in the patients with ovarian cancer than in the benign disease group and healthy normal controls,respectively (P<001～0001).At the cutoff value of 1.10,Cu/Zn ratio had a positive predictive rate (81.48%) between ovarian cancer patients and healthy normal controls.These findings suggest that Cu/Zn ratio may be used as a diagnostic index in patients with ovarian cancer.The nonconditional logistic regression multivariables analysis also showed that the serum Cu/Zn ratio of odds ratio (OR) was 59.80%,95% confidence interval (CI) 12.73～280.92.It is suggested that the risen serum Cu/Zn ratio may be a risk factor for ovarian cancer incidence.