摘要
为探讨非胰岛素依赖型糖尿病(NIDDM)患者凝血及纤溶活性,采用ELISA双抗体夹心法测定了35例NIDDM患者的血浆D-二聚体。结果:NIDDM患者血浆D-二聚体水平为1.63mg/L±0.14mg/L),明显高于正常对照组(0.33mg/L±0.09mg/L)(P<0.05);有血管病变组D-二聚体为2.62mg/L±0.68mg/L,高于无血管病变组(0.69mg/L±0.68mg/L),差异有显著性(P<0.001);血浆D-二聚体与FBG、TC、TG相关分析表明D-二聚体与FBG、TG呈正相关(分别为r=0.58,P<0.001;r=0.035,P>0.2;n=14),与TC呈负相关(r=-0.045,P>0.2,n=14)。8例NIDDM患者治疗后血浆D-二聚体较治疗前显著降低,分别为1.11±0.81,3.65±1.22,P<0.05)。提示NIDDM患者体内存在高凝和继发纤溶活性亢进,血浆D-二聚体是反映NIDDM患者高凝和缺血性疾病的诊断、疗效观察的良好指标。
In order to investigate the NIDDM patients coagulability as well as fibrinolysis,we measured thirtyfive NIDDM patients′ plasma concentration of Ddimer by a sandwichELISA assay with two selfmade McAbs.Result:The average concentration of Ddimer is 1.63mg/L±0.14mg/L.It is higer than that of healthy man(which is 0.33mg/L±0.09mg/L)(P<005).Patients with vascular disease have a higher level of Ddimer than patients without vascular disease,they are 2.62mg/L±0.68mg/L and 0.69mg/L±0.68mg/L;there is a significant discrepancy between the two groups (P<0001).The analysis of relationship between the plasma concentration of Ddimer and FBG,TC,TG,showed that Ddimer is strongly related to FBG and TG(they are r=0.58,P<0.0001;r=0.035,P>0.2,n=14).However,Ddimer is inversely related to TC(r=-0.0045,P>0.2,n=14).Eight patients′ Ddimer greatly decreased after the treatment,becoming 1.11±0.81,3.65±1.22,P<0.05.This article provides evidence that in NIDDM patients,bodies there exist high coagulation and successive accentuation of fibrinolysis.For the diagnosis and therapeutic effect on patients with high coagulation and ischemic disease the plasma level of Ddimer is a fairly good index.
出处
《山西医药杂志》
CAS
1997年第6期496-497,共2页
Shanxi Medical Journal
关键词
糖尿病
D-二聚体
纤溶活性
NIDDM
noninsulindependent diabetes mellitus Ddimer fibrinolysis