产后抑郁症的相关问题分析

To Analyze Relative Questions on Postnatal Depression

目的探讨产后抑郁症(postnatal depression)的相关因素及其发病机制。方法本研究采用《爱丁堡产后抑郁量表》(Edinburgh Postnatal Depression Scale,EPDS),以2005年1月至2005年12月在本院妇产科住院分娩的1 347例产后诊断为抑郁症的患者146例为研究对象(观察组),与同期分娩的正常产妇146例进行对照(对照组),观察其发病率、诱因、病史及对新生儿的影响。结果本研究显示,产后抑郁症发病率为10.96%(146/1 332),43.84%有明确诱因(64/146);有经前综合征病史的患者,观察组发病率高于对照组(P<0.01);产时出血量比较,观察组多于对照组(P<0.01);所生新生儿发生激惹比较,观察组多于对照组(P<0.01)。结论产后抑郁症患者存在明显的性激素骤变,推测抑郁症可能由性激素异常变化引起。

Objective To investigate relative factors and pathogenesis with postnatal depression. Methods 146 cases with postnatal depression （the test group） were diagnosed by Edingburgh Postnatal Depression Scale （EPDS）, and the control group had 146 cases of normal parturition. The incidence of postnatal depression, effect of inducements and medical history on the newborns were investigated. Results The occurrence rate of postnatal depression was 10. 96%（146/1 332）, and 43.84%（64/146） of them have the clear cause. Among the patients with premenstral syndrome, the occurrence rate in the test group was higher than that in the control group （P〈0.01）. Compare the serious partus-hemorrhage, the test group was higher than that in the control group （P〈0.01）, and the newborns of the test group were more irritable in the parturition of postnatal depression （P〈0.01）. Conclusion There are significant changes of sex hormones in postnatal depression patients, we presume that postnatal depression is caused by abnormal changes of sex hormones.