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不同日龄新生儿凝血指标的临床研究 被引量:8

Coagulation index in newborn with different age
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摘要 目的探讨不同日龄新生儿凝血指标的变化及其临床意义。方法以我院2005年1至12月129例生后无合并症新生儿为研究对象。按胎龄分为足月儿组和早产儿组,分别于生后1、3、10d采血测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fg)、凝血酶时间(竹)及D-二聚体含量。结果在出生后1.3、10d三个不同日龄。早产儿和足月儿两组间的PT、D-二聚体差异均无显著性(P〉0.05),但早产儿组的APTT、TT在三个不同的日龄均高于足月儿,Fg低于足月儿,差别均有显著性(P〈0.05)。同时随着新生儿13龄的增加,PT、APTT、TT、D-二聚体减少,而Fg增加,三个时间点凝血指标的差别均有显著性(P〈0.05)。结论胎龄、日龄对新生儿凝血指标均有影响,为临床诊断和治疗提供了一定的参考依据。 Objective To expolore the changes of coagulation index in newborns of different age and its clinical significance. Methods We studied 129 newborn infants without complication admitted to the neonatal department in an all-around hospital in Guangzhou from January to December in 2005. These neonates were divided into two groups, including 63 cases of full-term infants and 66 eases of premature infants. Prothrombin time (PT), activated partial prothrombin time (APTT), Fibrinogen (Fg), thrombin time (TT), D-dimer (D-D) of these newborn infants were assayed on the first day, the third day and the tenth day. Results In the postnatal three periods of time, there was no difference in PT and D-dimer between two groups(P〉0.05), but APTT and TT in premature infants were higher than that in full-term infants(P 〈0.05), and Fg in premature infants were lower than that of full-term infants( P 〈0.05). PT, APTT, TT, D- dimer were in decrease tendency and Fg increased as age increased( P 〈 0.05 ). Conclusion Gestational age and age had effect on coagulation index in newborn infants, and both can provide clinical references to clinical diagnosis and therapy.
出处 《中国小儿急救医学》 CAS 2008年第5期430-432,共3页 Chinese Pediatric Emergency Medicine
关键词 新生儿 日龄 凝血指标 Newborn Age Coagulation index
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参考文献5

  • 1Autret-Leca E, Jonville-Bera APP. Vitamin K in neonates: how to administer, when and to whom. Paediatr Drugs, 2001, 3 (1) : 1-8.
  • 2Williams MD, Chalmers EA, Gibson BE, et al. The investigation and management of neonatal haemostasis and thrombosis. Br J Haematol, 2002,119(2) :295-309.
  • 3张国荣,王少峰,范秀芳,徐强(编校).早产儿凝血功能特点及其与出血的关系[J].中国妇幼保健,2007,22(5):607-608. 被引量:14
  • 4刘兰.危重新生儿弥散性血管内凝血前期的监测与治疗[J].实用儿科临床杂志,2006,21(14):910-911. 被引量:14
  • 5Knofler R, Hofmann S, Weisshach G, et al. Molecular markers of the endothelium, the coegulation and the fibrinolytic systems in healthy newborns. Semin Thromb Hemost, 1998, 24 ( 5 ) : 453-461.

二级参考文献22

  • 1韦丹,陈玉君.肝素并低分子右旋糖酐对危重新生儿血清D-二聚体的影响[J].小儿急救医学,2004,11(5):315-316. 被引量:3
  • 2毕玫荣,张岩.新生儿凝血特点及其影响因素[J].国外医学(妇幼保健分册),2005,16(1):15-17. 被引量:48
  • 3楼金吐,孔宏伟,俞锡林.新生儿凝血因子水平及其意义[J].临床检验杂志,1995,13(4):176-178. 被引量:16
  • 4金汉珍 黄德珉 官希吉.实用新生儿(第3版)[M].北京:人民卫生出版社,2003.421-427.
  • 5Hyyti S,Syr M,Fellman V,et al.Fresh frozen plasma reduces thrombin formation in newborn infants[J].Thromb Haemost,2003,1(6):1189-1194.
  • 6Ries M,Kling J,Rauch R.Age-related reference values for activation markers of the coagulation and fibrinolytic systems in children[J].Thromb Res,1997,85(4):341-344.
  • 7Tay SP,Cheong SK,Boo NY.Circulating tissue factor,tissue factor pathway inhibitor and D-dimer in umbilical cord blood of normal term neonates and adult plasma[J].Blood Coagul Fibrinolysis,2003,14(2):125-129.
  • 8Suzuki S,Morishita S.Hypercoagulability and DIC in high-risk infants[J].Semin Thromb Hemos,1998,24(5):463-466.
  • 9El Beshlawy A,Hussein HA,Abou-Elew HH,et al.Study of protein C,protein S,and antithrombin Ⅲ in hypoxic newborns[J].Pediatr Crit Care Med,2004,5(2):163-166.
  • 10Guzzetta NA,Miller BE,Todd K,et al.An evaluation of the effects of standard heparin dose on thrombin inhibition during cardiopulmonary bypass in neonates[J].Anesth Analg,2005,100(5):1276-1282.

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