不同日龄新生儿凝血指标的临床研究

Coagulation index in newborn with different age

目的探讨不同日龄新生儿凝血指标的变化及其临床意义。方法以我院2005年1至12月129例生后无合并症新生儿为研究对象。按胎龄分为足月儿组和早产儿组，分别于生后1、3、10d采血测定凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（Fg）、凝血酶时间（竹）及D-二聚体含量。结果在出生后1．3、10d三个不同日龄。早产儿和足月儿两组间的PT、D-二聚体差异均无显著性（P〉0．05），但早产儿组的APTT、TT在三个不同的日龄均高于足月儿，Fg低于足月儿，差别均有显著性（P〈0．05）。同时随着新生儿13龄的增加，PT、APTT、TT、D-二聚体减少，而Fg增加，三个时间点凝血指标的差别均有显著性（P〈0．05）。结论胎龄、日龄对新生儿凝血指标均有影响，为临床诊断和治疗提供了一定的参考依据。

Objective To expolore the changes of coagulation index in newborns of different age and its clinical significance. Methods We studied 129 newborn infants without complication admitted to the neonatal department in an all-around hospital in Guangzhou from January to December in 2005. These neonates were divided into two groups, including 63 cases of full-term infants and 66 eases of premature infants. Prothrombin time （PT）, activated partial prothrombin time （APTT）, Fibrinogen （Fg）, thrombin time （TT）, D-dimer （D-D） of these newborn infants were assayed on the first day, the third day and the tenth day. Results In the postnatal three periods of time, there was no difference in PT and D-dimer between two groups（P〉0.05）, but APTT and TT in premature infants were higher than that in full-term infants（P 〈0.05）, and Fg in premature infants were lower than that of full-term infants（ P 〈0.05）. PT, APTT, TT, D- dimer were in decrease tendency and Fg increased as age increased（ P 〈 0.05 ）. Conclusion Gestational age and age had effect on coagulation index in newborn infants, and both can provide clinical references to clinical diagnosis and therapy.