丙泊酚应用于ICU病人镇静的临床观察

Clinical Observation of Propofol Applied in Sedation of ICU Patients

目的:观察丙泊酚在ICU病人镇静治疗中应用方法及疗效观察;方法:治疗组50例术后及危重病患者,采用微量注射泵持续静脉注入丙泊酚;对照组;20例ICU病人,采用咪达唑仑微量泵持续静脉注入。结果:总镇静时间对照组为(28.2±8.2)h,治疗组为(25.5±5.5)h;药物起效时间治疗组为(29.3±7.6)s,对照组为(65.1±11.3)s,治疗组和对照组比较有显著性差异(P<0.01)。达到满意镇静深度时间治疗组为(23±11)min,对照组(38±17)min(P<0.01)。对照组清醒时间需2～400min,治疗组需1～103min。两组用药前后主要生命指标比较无显著性意义(p>0.05)。结论:丙泊酚起效快作用时间短,撤药后迅速清醒,能达到病人所需的镇静要求,根据临床调整镇静时间和深度,保证了ICU临床各项医医疗护理工作的有序进行,促进病人康复。

Objective： To observe the application and efficacy of propofol in sedation therapy of ICU patients. Methods： Therapy group： 50 patients after surgery or in critical situations were infused propofol continuously into veins by micromedicine infusion pump; Control group： 20 ICU patients were infused midazolam into veins continuously also by micromedicine infusion pump. Results： 1.The total time for calm：the control group （28.2±8.2）h,the therapy group （25.5±5.5）h, The drug onset time：the therapy group （29.3±7.6）s,the control group（65.1±11.3）s, there was significant differences between the two groups,（P〉0.01）. 2. The time needed to achieve satisfy sedation depth： the therapy group （23±11） min, the control group （38± 17） min, （P〈0.01）. 3.The conscious time： the control group 2-400min, the therapy group 1 -103min. 4.There were no remarkable differences in the vital signs of patients between the two groups fore and after the medication,（P〉0.05）. Conclusions： propofol has shorter act time and active quickly, the patients could sober soon after drug withdrawal . It can meet all the patients＇ sedation needs and can be modified sedation time＇ and depth. All of these could guarantee the treatment and nursing activities of ICU in good order which is also beneficial to the rehabilitation of patients.