纳络酮在重症颅脑损伤治疗中的疗效观察

The Effect of Naloxone in the Treatment of Severe Brain Injury

目的:为了探讨早期应用纳络酮(NLX)在急性重症颅脑损伤治疗中的作用。方法:我们在两年内对收治的急性重症颅脑损伤患者随机分为治疗组(64例)和对照组(70例)。对两组病人的死亡率、伤残率和痊愈率进行统计学处理分析。结果:发现NLX治疗组病人的死亡率、伤残率明显低于对照组,P<0.05,痊愈率明显高于对照组,P<0.05。结论:早期应用纳络酮可有效降低急性重症颅脑损伤患者的伤残率和死亡率。

Objective： To investigate the role of early application of naloxone （NLX） in the treatment of acute severe brain injury. Method： Within two years of the treated patients with acute severe brain injury in our hospital were randomly divided into treatment group （64 cases） and the control group （70 cases）, the two groups of patients mortality, disability rate and the cure rate for statistical analysis Analysis. Results： NLX treatment group patient＇s mortality, disability was significantly lower than the control group, P〈0.05, significantly higher cure rate, P 〈0.05. Conclusions： The early application of naloxone can effectively reduce the disability rates and mortality rates of patients with acute severe brain injury.