老年OMI患者PAI-1、AT-Ⅲ与颈动脉IMT的相关性研究

A Study on the Association Between PAI-1,AT-Ⅲand Carotid Artery Intima-media Thickness in Elderly Patients with Old Cardial Infarction

目的:探讨老年陈旧性心肌梗死(OMI)患者纤溶酶原激活物抑制剂-1(PAI-1)、抗凝血酶-Ⅲ(AT-Ⅲ)与颈动脉内膜-中层厚度(IMT)的关系。方法:共入选56例OMI患者,采用B-型超声诊断仪检查颈动脉IMT,同时检测AT-Ⅲ、PAI-1水平。以颈动脉IMT作因变量,AT-Ⅲ,PAI-1,血浆纤维蛋白原(FBN)等13个变量作为自变量,采用逐步筛选法进行多元线性回归分析。结果:1、PAI-1等7个变量进入方程:IMT=-0.5431+0.0438FBN+0.0831PAI-1+0.0024SBp+0.0023Age+0.1725LDL-0.1256HDL+0.3733Apo-B。提示:PAI-1与颈动脉IMT正相关,是IMT增厚的独立危险因素;AT-Ⅲ未进入回归方程,表明其与颈动脉IMT增厚无相关。2、对PAI-1、AT-Ⅲ与颈动脉IMT的关系分别进行直线相关分析,其结果分别为:IMT=-0.2039+0.5343PAI-1,r=0.8221.P<0.0001;IMT=0.8538+0.0006AT-Ⅲ,r=0.1095,P=0.4215。此结果亦表明:PAI-1水平与IMT呈正相关;AT-Ⅲ与颈动脉IMT增厚无相关。结论:老年OMI患者病情稳定时,PAI-1与颈动脉IMT呈正相关,是颈动脉IMT增厚的危险因素;AT-Ⅲ与颈动脉IMT增厚无相关。

Objective： To investigate the relationship between PAI-1,AT-Ⅲ and carotid artery intima-media thickness （IMT）in the elderly patients with old myocardial infarction. Method： The IMT of fifty six elderly patients with old myocardial infarction was detected with B-mode Doppler. At the same time their PAI-1,AT-Ⅲ indexes were measured. IMT was treated as dependent variable and PAI-1, AT-Ⅲ etc were treated as independent variables. We did the multiple linear regression with stepwise selection method. Results： 1.Seven variables （PAI-1 etc） were allowed entries into the regression model. IMT=-0.5431＋0.0438FBN＋0.0831PAI-1＋0.0024SBp＋0.0023Age＋ 0.1725LDL-0.1256HDL＋0.3733Apo-B,PAI-1 R^2= 0.0029, b=0.083l, b＇=0.1290o This indicate that PAI-1 is positive correlation with IMT , It is the risk factor to the increasing of IMT. ;AT-Ⅲ was not allowed entries into the regression model, This indicate that AT-Ⅲ was not correlation with IMT. 2, We did the simple linear regression to PAI-1 ,AT-Ⅲ with IMT respectively. The result respectively is： IMT=- 0.2039＋0.5343PAI-1, r=0.8221, P〈0.0001：IMT=0.8538＋0.0006 AT-Ⅲ, r=0.1095, P=-0.4215. This indicates that the PAI-1 level is the positive correlation to IMT. And AT-Ⅲ is not correlation with IMT. Results When the elderly patients with old myocardial infarction are in a stable stage, PAI-1 level shows positive correlation to IMT. This indicates that the the PAI-1 level is a harm factor to the increasing of IMT; and AT-Ill is not correlation with IMT.