缰核与奖赏和稳态

Reward,Homeostasis and the Habenula

奖赏可以激励动物去进行和维持与个体生存和种族延续有关的行为。有机体在完成这些行为所进行的稳态调节过程中,从总体上要经历和脑内多巴胺神经元的活动密切相关的奖赏预测和奖赏预测失误。外侧缰核神经元在无奖赏预测过程中对多巴胺神经元有强力抑制作用。保持稳态平衡是机体活动的根本目标,奖赏是推动稳态平衡的驱动力。缰核能独立完成奖赏功能,并参与众多与生命活动攸关的生理功能调节,所以它可能也是机体稳态调节的中心之一。

Reward is the behavior that inspires the subject to engage in various forms of behavior for the survival and reproduction. Reward prediction, reward prediction error and the brain processes induced by them are necessary for the homeostasis with the fine regulations. These processes are closely involved in the activity of dopamine neurons in the brain. Lateral habenula regulates the activity of dopamine neurons in the midbrain. Lateral habenula neurons are excited while the unpredictable reward exists, and the do- pamine neurons are strongly inhibited. Homeostasis sustained is the goal of the functional regulation of the living body . Reward is the driving power of forcing the living body to achieve homeostasis . Habenula can independently perform the reward function. And it also participates in the regulations of the major physiological functions. Therefore habenula may also be one of the center in the brain of homeostatic regulation.