摘要
动脉粥样硬化(AS)发生机制十分复杂,目前认为其病变的发生与发展是趋化因子、细胞因子和活性代谢产物等综合作用的结果。其中单核细胞趋化蛋白1(MCP-1)被认为是AS发生早期的关键因素,它对单核细胞具有很强的趋化活性,可以介导单核细胞黏附血管壁并迁移进入内膜下层,促发斑块的形成并对斑块的去稳定具有重要的作用。本综述了MCP-1在动脉粥样硬化炎性反应过程中的作用,以及治疗AS疾病的可行方案。
The mechanism of atherosclerosis is very complicated, and its occurrence and development were thought to be the results from joint effects of chemokines, cytokines, active metabolite. Among them, monocyte chemoattractant protein-1 （ MCP-1 ） is considered for a critical factor in the formation of atheroscle- rotic plaques, which has strong and specific chemotactic activity on monocytes, mediates monocytes to adhere to the blood vessel wall and then transfere into the underlayer of endomembrane, urge the formation of plaque,and also has important effect on the de - stabilization of plaques. This paper reviewed the roles of MCP-1 in the mechanism of atherogenesis and the effect of MCP-1 on atherosclerosis, also provided a feasible therapy tragedy of As.
出处
《医学综述》
2008年第20期3050-3052,共3页
Medical Recapitulate
基金
湖南省自然科学基金(06JJ30016)
