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干扰素γ对角质细胞与破骨细胞的影响 被引量：3

The Effect of IFN-γ to the Keratinocyte and Osteoclast
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摘要 干扰素γ(IFN-γ)是Th1细胞的标志性细胞因子,与机体多种疾病的发生有密切关系。IFN-γ可以通过促进角质细胞的增生并抑制其凋亡,刺激破骨细胞的形成,在银屑病、特异性皮炎等的上皮增生及类风湿性关节炎、骨质疏松等的骨质破坏过程中发挥重要作用。本文就IFN-γ对角质细胞与破骨细胞的影响及其在中耳胆脂瘤发病中的作用予以概述。 Interferon-γ （IFN-γ） is a label cytokine produced by Thl cell and related to various diseases. IFN-γ stimulates the proliferation, inhibit the apoptosis of horny cells, and improve the production of osteoclast, which plays important roles in psoriasis atopic dermatitis, arthritis, osteoporosis and so on. This article summarized the effects of IFN-γ in the keratinocyte and osteoclast,and its roles in the pathogenesy of in middle ear cholesteatoma.
作者 金玲爽 沈志忠
机构地区 汕头大学医学院第一附属医院耳鼻喉-头颈外科
出处 《医学综述》 2008年第20期3064-3067,共4页 Medical Recapitulate
关键词 干扰素Γ 角质细胞 破骨细胞 中耳胆脂瘤 Interferon-γ Keratinoeyte Osteoclast Middle ear cholesteatoma
分类号 R739.61 [医药卫生—肿瘤]
  • 相关文献

参考文献21

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二级参考文献29

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共引文献23

同被引文献25

  • 1任晓勇,陈文弦,崔鹏程,张全安.中耳胆脂瘤上皮中白介素-1α的表达[J].中国耳鼻咽喉头颈外科,2005,12(6):367-369. 被引量：5
  • 2胡向农,魏强.CpG ODN诱导浆细胞样树突状细胞免疫调节的作用机制[J].现代免疫学,2005,25(4):337-340. 被引量：3
  • 3陈晓飞,邓敏.Toll样受体病原识别及信号转导的研究新进展[J].中国感染控制杂志,2006,5(3):282-285. 被引量：2
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医学综述
2008年 第20期

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