摘要
干扰素γ(IFN-γ)是Th1细胞的标志性细胞因子,与机体多种疾病的发生有密切关系。IFN-γ可以通过促进角质细胞的增生并抑制其凋亡,刺激破骨细胞的形成,在银屑病、特异性皮炎等的上皮增生及类风湿性关节炎、骨质疏松等的骨质破坏过程中发挥重要作用。本文就IFN-γ对角质细胞与破骨细胞的影响及其在中耳胆脂瘤发病中的作用予以概述。
Interferon-γ (IFN-γ) is a label cytokine produced by Thl cell and related to various diseases. IFN-γ stimulates the proliferation, inhibit the apoptosis of horny cells, and improve the production of osteoclast, which plays important roles in psoriasis atopic dermatitis, arthritis, osteoporosis and so on. This article summarized the effects of IFN-γ in the keratinocyte and osteoclast,and its roles in the pathogenesy of in middle ear cholesteatoma.
出处
《医学综述》
2008年第20期3064-3067,共4页
Medical Recapitulate
关键词
干扰素Γ
角质细胞
破骨细胞
中耳胆脂瘤
Interferon-γ
Keratinoeyte
Osteoclast
Middle ear cholesteatoma