期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

葡萄糖转运蛋白1与妇科肿瘤的关系 被引量：1

The Relationship between the GLUT1 with the Obstetrics Tumor
下载PDF
导出
摘要 葡萄糖转运蛋白(GLUT)是分布在细胞膜的跨膜糖蛋白,介导葡萄糖在细胞膜两侧的转运。不同的GLUT在组织中的分布、功能、调控机制等方面均存在差异。研究发现,肿瘤细胞表面有异常的GLUT的表达,尤其是GLUT1。GLUT1的高表达可以作为细胞恶性转化的标志,并与肿瘤细胞的增殖、侵袭能力、转移密切相关,可能对肿瘤的早期诊断及判断预后提供新的依据。 GLUT is a sugar-protein in cell membrane,which responses for the transport of sugar in the cell membrane. The distribution, function, regulation of different kinds of GLUT are different in tissues. GLUT is highly expressed in tumor cells, especially GLUT1. The high expression is a marker of the cell malignant transformation and relates with the tumor cell growing,invasion ability and metastasis. It may provide a new proof to the early diagnose and may be a useful predictor of poor prognosis.
作者 雷永凤
机构地区 三台县人民医院妇产科
出处 《医学综述》 2008年第20期3093-3095,共3页 Medical Recapitulate
关键词 葡萄糖转运蛋白 肿瘤 氟-脱氧葡萄糖 正电子发射计算机体层扫描 Glucose transporter Tumor F-Fluordeoxyglukose Positron emission tomogTaphy
分类号 R737 [医药卫生—肿瘤]
  • 相关文献

参考文献6

二级参考文献76

  • 1朱宏,施瑞华.缺氧诱导因子与肿瘤血管生成[J].国外医学（肿瘤学分册）,2004,31(8):591-594. 被引量：21
  • 2Tian H, Hammer RE, Matsumoto AM, et al. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev, 1998,12(21 ): 3320-3324.
  • 3Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol,2000, 157(2) :411-421
  • 4Gu YZ, Moran SM, Hogenesch JB, et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr, 1998, 7(3):205-213.
  • 5Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxiainducible factor lalpha in common human cancers and their metastases.Cancer Res, 1999, 59(22) :5830-5835
  • 6Na X, Wu G, Ryan CK, et al. Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. J Urol, 2003, 170(2 Pt 1):588-592.
  • 7Liu MY, Pcellinger L, Walker CL. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res, 2003,63 (10): 2675-2680.
  • 8Mizukami Y, Li J, Zhang X, et al. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res, 2004, 64(5): 1765-1772.
  • 9Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer, 2003,97(6): 1573-1581.
  • 10Buchler P, Rebar HA, Buchler M, et al. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas, 2003,26(1) :56-64.

共引文献45

同被引文献7

  • 1冯卿卿,陈素琴,王振海.腹腔液的病理学诊断进展[J].国外医学（妇产科学分册）,2006,33(6):417-420. 被引量：1
  • 2Tuzun Y,Yilmaz S,Dursun M,et al.How to increase the diagnostic value of malignancy-related ascites:discriminative ability of the ascietic tumor markers[J].J In Med Res,2009,37(1):87-95.
  • 3Kurman R J,Ellenson LH,Ronnett BM.Blaustein's pathology of the female gential tract[M].6th ed.New York:SSBM,2010.698-700.
  • 4Ozcan A,Deveci MS,Oztas E,et al.Prognostic value of Glut-1expression in ovarian surface epithelial tumors:a morphometric study[J].Anal Quant Cytol Histol,2005,27 (4):181-186.
  • 5Yasuda M,Miyazawa M,Fujita M,et al.Expression of hypoxia inducible factor-1α (HIF-1ot) and glucose transporter-1 (Glut-1)in ovarian adenocarcinomas:difference in hypoxic status depending on histological character[J].Oncol Rep,2008,19(1):111-116.
  • 6Iida T,Yasuda M,Miyazawa M,et al.Hypoxic status in ovarian serous and mucinous tumors:relationship between histological characteristics and HIF-1 α/Glut-1 expression[J].Arch Gynecol Obstet,2008,277 (6):539-546.
  • 7Mensch LS,Weller L,Simmons-Arnold L,et al.Glut-1antibody staining in thin-layer specimens of benign and malignant body cavity effusion[J].Acta Cyt,2002,46(5):813-818.

引证文献1

医学综述
2008年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部