免疫抗毒散的毒性试验

The Toxicity Test of Immuno-antitoxicant Powder

免疫抗毒散为纯中药制剂,经动物试验,其对20日龄罗曼母鸡的最大耐受量在35g/lg体质量以上,灌胃最大耐受量为32g/kg体质量,20%免疫抗毒散小白鼠腹腔LD50=0.3mL/20g体质量,LD50的95%的可信限为0.240～0.376 mL/20g体质量;以20%的浓度给小白鼠和雏鸡连续饮水20d,用药期间小白鼠和雏鸡的精神、食欲、生长发育均正常,剖解时组织器官无任何形态学变化;给孕鼠饮水20d,产仔数和仔鼠的发育与对照组无差异,表明使用免疫抗毒散非常安全。

Immuno- antitoxicant powder is pure Chinese herb powder, the maximum tolerance dose of immuno- antitoxicant powder was exceed 35g/kg to 20days luoman hens by animal experiment, the maximum tolerance dose by intragastric administration was exceed 32g/kg. The LD50 was 0.3mL/20g when Mus musculus albus were dosaged by abdominal cavity with 20% immuno - antitoxicant powder. The confidence limit of 95% LDs0 was 0.240 -0. 376 mL/20g. The appetite and growth and development of Mus musculus albus and chicken, were normal after being drinked continuity 20days with 20% immuno-antitoxicant powder, tissue organs were not any morphology change after dissecting. The production number and development of young mouse were not discrepancy with control group. The test showed that the immuno - antitoxicant powder was very secure.