摘要
对10例肾移植患者作山地明转换Neoral试验，行药效动力学对比研究。30例新移植患者应用Neoral进行临床观察。结果，Neoral最高血浓度较山地明高282±84，达峰时间短0.79±0.29，CsA暴露大1533±169（P＜0.05）。Neoral有较好的抗排斥作用．但由于吸收迅速，血药浓度显超过治疗窗水平，引起肝中毒达20％。因此，我们认为Neoral与山地明转换，比例应用1:0．8～1：0．9，以免毒副作用发生。本组观察36月，Neoral服药量可较山地明常规剂量减少25％。
A clinical study of effects of Gyclosporin Neoral (Neoral) on anti-rejection in 40 cases of cadaverie renal transplantation re cipienls was carried out. Compared with sandimmun oral solution, the Tmax of Neoral was shorter, the Cmax was higher, the AUC of CsA was larger of (P<0.05,n=10), the Neoral dose could be reduced 25%. The main side effects include hepalotoxicity (20%) which were closely related to the CsA blood level. From the results we have obtained it can be concluded that Neoral has a good antirejection effect and a better absorption.
出处
《苏州医学院学报》
1997年第5期851-852,共2页
Acta Academiae Medicinae Suzhou
