难治性功能性消化不良并发抑郁、焦虑情况及干预治疗效果

Efficacy of Intervention with Combined Therapy on Refractory Functional Dyspepsia Complicated with Depression and Anxiety

目的探讨抑郁、焦虑与难治性功能性消化不良(functional dyspepsiaFD)的关系及抗抑郁药对其的疗效。方法对照620例常规治疗好转的FD患者与620例难治性FD患者,使用综合医院焦虑、抑郁量表(the Hospital anxiety and depressive scale HADS)进行心理测评。用抗抑郁药阿米替林治疗并发抑郁和(或)焦虑的难治性FD患者,疗程为8周,治疗后行HADS评分。并记录评价治疗前后躯体症状情况。结果难治性FD患者抑郁和(或)焦虑患病率(91.9%)和HADS评分与对照组之间差异有非常显著性(P<0.01),并发抑郁和(或)焦虑的难治性FD患者接受抗抑郁药治疗8周后,精神和躯体症状均有明显改善。结论难治性FD患者与抑郁、焦虑有关,抗抑郁药治疗能显著改善精神和躯体两方面症状。

Objective To explore the role of depression and anxiety in refractory functional dyspepsia （FD） and the efficacy of antidepressant drug in treatment of refractory FD., Methods Totally 620 patients with refractory FD and 620 patients with ordinary FD were psychologically analyzed by using hospital anxiety and depressive scale （HADS）. Antidepressant drug （Amitriptyline） was used to treat refractory FD patients complicated with＂ depression and / or anxiety for 8 weeks, Psy- chological analysis was done after the treatment. And somatic symptoms were recorded and evaluated before and after treat- ment. Results There was significant difference in HADS and depression and/or anxiety between the two groups （P〈 0.01）. The somatic and psychological symptoms of refractory FD patients with depression and/or anxiety, improved signifi- cantly after 8 weeks treatment. Conclusions Depression and anxiety play the important roles in refractory FD patients. Antidepressant drug （Amitriptyline） is effective in improving the somatic and psychological symptoms of refractory FD.