低分子肝素对慢性心力衰竭伴肾功能不全患者血肌酐及脑钠肽的影响

Effects of low molecular heparin on serum creatinine and brain natriuretic peptide in patients with chronic heart failure associated with chronic renal insufficiency

目的探讨低分子肝素对慢性心力衰竭急性发作伴慢性肾功能不全患者近期顶后的影响。方法用酶联接免疫吸附剂测定(ELISA)方法检测慢性心力衰竭伴肾功能不全患者血浆脑钠肽(BNP)及血肌酐尿酸在治疗前后浓度的变化。结果低分子肝素治疗7天后试验组血肌酐及BNP明显下降,试验组与对照组比较差异有显著性意义(P<0.05)。结论短期低分子肝素治疗能显著降低慢性心衰急性发作患者血BNP及肌酐,可改善患者的近期预后。

Objective To investigate the effect of low molecular heparin on patients who suffered both chronic renal insufficiency and decompensated chronic heart failure by observing the serum levels of creatinine and brain natriuretic peptide. Methods A randomized way was adopted in this study to contrast 40 cases of decompensated chronic heart failure with cbronic renal insufficiency. 20 patients were assigned randomly to the low molecular beparin group （ low molecular heparin of 5000 U/d in addition to standard therapy） and the other 20 to the control group （standard therapy）. Serum levels of creatinine and brain natriuretic peptide were tested betore and ＇after treatment. Results After one week＇s treatment, both creatinine and BNP in low molecular heparin group were significantly reduced compared to the control group （P 〈 0. 05 ）. Conclusion Low molecular beparin can decreases creatinine and BNP levels in patients suffering decompensated chronic heart failure witb chronic renal insufficiency, and thus will improve their prognosis.