新生儿ABO溶血病早期治疗疗效分析

Clinical therapeutic effect of ABO hemolytic disease of newborn

目的探讨新生儿ABO溶血病的早期治疗效果：方法46例新生儿ABO溶血病患儿分为常规组（16例）和丙球组（30例），常规组采用静脉用白蛋白（1g／kg，1次／天，连用3天），蓝光照射，补液，碱化尿液，肝酶诱导剂，减少肠肝循环等治疗。丙球组常规治疗同时静脉应用丙种球蛋白[（O．5～t．0）g/（kg·d）]。两组治疗均在出生48小时内进行。结果两组患儿均痊愈出院；丙球组所需光疗时间、平均住院时间均较常规组缩短，差并均有显著性意义（P〈0．01），1周后血红蛋白Hb较常规组显著增加，差异有显著性意义（P〈0．01）。结论在常规治疗基础上，早期静脉应用大剂量种丙球蛋白能有效降低患儿胆红素水平，减少光疗与住院时间，降低贫血程度。

Objective To investigate the early treatment efficacy of ABO hemolytic disease of newborns. Methods 46 newborn infants with ABO hemolytic disease were divided into conventional therapy group （ 16 cases） and r-globulin therapy group （30 cases）. Patients in the conventional therapy＂ group were given conventional treatment protocols, including intravenous albumin （1 g/ kg, 1 / days, for 3 days）, Blu-ray irradiation, fluid infusion, urine basification, liver enzyme inducer, and measures to reduce the enterohepatic circulation. Patients in the r-globulin therapy group were given the conventional treatments mentioned above, and intravenous r-globulin [ （0. 5 - 1.0 ） g / i kg·d） ]. The treatments of the two groups were implemented within 48 hours of birth. Results All newborns were cured and discharged uneventfully. In r-globulin therapy group, the time for light therapy and the average length of hospital stay were significantly shorter than the conventional therapy group { P 〈0. 01 ） One week later, Hb increased significantly in r-globulin therapy group than the conventional therapy group （ P 〈 0. 01 ）. Conclusion In addition to conventional treatment, early （ within 48 hours of birth ） application of high dose of intravenous immunoglobuhn is effective to lower the levels of bilirubin, shorten the light therapy time and the length of stay, and ameliorate anemia.