口腔扁平苔藓癌变的临床研究(附9例报告)

Clinical study of oral Lichen planus canceration( affiliated 9 cases ).

目的:探讨口腔扁平苔藓(OLP)癌变发生特点及规律。方法:对668例OLP病例进行近19年的临床观察及随诊资料统计,并且所有病例均得到组织病理学证实。结果:共发现9例OLP癌变病例,癌变率为1.35%,女性明显多于男性。3例发生在口腔黏膜3个危险区。2例在外界刺激下发生癌变。糜烂型、斑块网纹型病损均可发生癌变。病程15个月至10年不等。结论:OLP癌变患者女性多于男性,口腔黏膜3个危险区好发,外界刺激可诱发癌变,OLP癌变与病损类型无明显关系,癌变病程长。

Objective： to discuss the the characteristic and pattern of canceration caused by（OLP）. Method： 668 oral lichen planus （OLP） cases had been observed and statistically analyzed for 19 years, all cases were histopathologically verified . Result： Total 9 cases of oral lichen planus（OLP）canceration were found with the ratio of 1.35%, the probability of canceration to female obviously exceeded that of male. 3 cases were found occurrence at three dangerous areas of oral mucous membrane. 2 cases were developed cancer by external stimulus. Canceration can be developed either from anabrosis injury or parapsoriasis reticulatus injury. Course of canceration ranged from 15 monthes to 10 years. Conclusion： Probability of OLP canceration to female exceeded that of male. It is frequently occurred at three dangerous areas of oral mucous membrane. Canceration can be developed by external stimulus. OLP canceration has nothing to do with the type of injuries. Course of canceration is rather long.