期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胰岛素抵抗大鼠血管内皮功能的研究 被引量：3

下载PDF
导出
摘要 目的探讨胰岛素抵抗(IR)大鼠血管内皮功能状态。方法雄性Wistar大鼠分为对照组、高脂组,喂养8w,用高胰岛素-正血糖钳夹技术稳态时葡萄糖输注率(GIR)评价IR;测定内皮型一氧化氮合酶(eNOS)及血管壁一氧化氮(N0)含量。结果GIR在两组间出现显著差异(P<0.01);高脂组大鼠血清游离脂肪酸(FFA)、甘油三酯(TG)、肿瘤坏死因子-α(TNF-α)水平高于对照组;高脂组大鼠血管内皮细胞中eNOS及NO含量明显降低(P<0.01);相关分析显示,血管壁NO含量与FFA、TNF-α呈负相关,而GIR与NO存在显著的正相关。结论IR大鼠血糖正常阶段已经存在内皮功能障碍,血中FFA、TNF-α的升高可能直接参与内皮功能障碍的发生发展。
作者 何冰 赵晟 王艳军
机构地区 中国医科大学附属盛京医院内分泌科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第19期1899-1900,共2页 Chinese Journal of Gerontology
关键词 胰岛素抵抗 内皮功能障碍 游离脂肪酸 肿瘤坏死因子-Α
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献7

  • 1Wheatcroft SB, Williams IL, Shah AM, et al. Pathophysiological implications of insulin resistance on vascular endothelial function[J].Diabet Med,2003 ;20(14) :255-68.
  • 2Hsueh WA, Lyon C J, Quinones MJ. Insulin resistance and the endothelium [J]. Am J Med,2004;117(2) :109-17.
  • 3向光大.胰岛素抵抗与血管内皮功能[J].中华糖尿病杂志（1006-6187）,2005,13(5):321-323. 被引量：21
  • 4O'Brien SF, Russell JC, Dolphin P J, et al. Vascular wall function in insulin-resistant JCR : LA-CP rats: role of male and female sex [J]. J Cardiovasc Pharmacol,2000 ;36 : 176-81.
  • 5Esenabhalu VE, Schaeffer G, Gsaier WF. Free fatty acid overload attenuates Ca^2 + signaling and NO production in endothelial cells[ J]. Antioxid Redox Signal,2003 ;5 (2) : 147-53.
  • 6娄金荣,盛净.胰岛素抵抗与内皮功能障碍[J].心血管病学进展,2005,26(B08):117-119. 被引量：8
  • 7Anderson TJ. Nitric oxide, atheroscherosis and the clinical relevance of endothelial dysfunction[J]. Heart Fail Rev ,2003 ;8 ( 1 ) :71-86.

二级参考文献18

  • 1Madonna R, Pandolfi A, Massaro M,et al. Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a proatherogenic pathway mediated by p38mitogen-activated protein-kinase[J]. Diabetologia, 2004,47 ( 3 ) : 532 -536.
  • 2Chen NG,Holmes M ,Gerald M ,et al. Relationship between insulin resistance,soluble adhesion molecules,and mononuclear cell binding in healthy volunteers[J]. J Clin Metab Endocrinol, 1999,84:3485-3489.
  • 3Laakso M, Edelman SV, Brechtel G, et al. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance[ J ]. J Clin Invest, 1990,85 ( 6 ) : 1844-1852.
  • 4Steinberg HO, Brechtel G, Johnson A, et al. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release[J]. J Clin Invest, 1994,94 ( 3 ) : 1172-1179.
  • 5Steinberg HO ,Chaker H ,Learning R, et al. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance[ J ]. J Clin Invest, 1996,97 ( 11 ) :2601-2610.
  • 6Kuboki K,Jiang ZY ,Takahara N ,et al. Regulation of endothelial consthutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin [ J ]. Circulation, 2000,101:676-681.
  • 7Hermann C, Assmus B, Urbich C,et al. Insulin-mediated stimulation of protein kinase Akt : A potent survival signaling cascade for endothelial cells[J ]. Arterioscler Thromb Vasc Biol,2000,20 (2) :402-409.
  • 8Brame L,Verma S, Anderson T,et al. insulin resistance as a therapeutic target for improved endothelial function: metformin [ J ]. Curt Drug Targets Cardiovasc Haematol Disord,2004,4( 1 ) :53-63.
  • 9Anderson TJ. Nitric oxide,atherosclerosis and the clinical relevance of endothelial dysfunction [J]. Heart Fail Rev ,2003,8( 1 ) :71-86.
  • 10Boden G, Carnell LH. Nutritional effects of fat on carbohydrate metabolism [ J ].Best Pract Res Clin Endocrinol Metab,2003,17(3):399-410.

共引文献27

同被引文献6

引证文献3

二级引证文献7

中国老年学杂志
2008年 第19期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部