我院34例药害事件发生的原因分析

Analysis on Causes of 34 Drug-Induced Injury Event Cases in Our Hospital

通过对我院近5年间临床诊断并住院治疗的34例药害事件病历回顾性分析和归类,总结药害事件发生的原因。药害事件中ADR12例,ADE22例。药害事件与年龄、性别无关;药品剂型以注射剂为主(占91.18%),药品种类以抗菌药物最多(占29.41%)、中成药次之(23.53%);在所有累及的系统-器官中,全身性损害居第1位(占35.29%),临床表现复杂多样,以过敏性休克最多(20.59%)。药害事件除了和药物的不良反应有关外,还与药物选择不当,不合理配伍,长期、超剂量用药和溶媒选择不合理等因素有关。

The causes of 34 drug-induced injury event cases were analyzed by retrospectively reviewing patients who had been diagnosed as having drug-induced injury event and hospitalized in our hospital over the past 5 years. The 34 cases, include 12 ADR cases and 22 ADE cases, bad no difference with age or sex. The type of drug took injection as a lord （91.18%）, and most injury events were caused by anti-virus drugs （29.41%）. followed by the Chinese medicines （23.53%）. All the systems and organs impaired, general impairment of the body was the first （35.29%）, clinical manifestation was diverse, but allergic response was the most type （20.59%）. The causes of injury events connected with ADR, returning to choose drugs and menstruum without appropriate, incompatible use, long-time and exceeding a normal measure of drug etc.