醋蒜提取物对几种肿瘤细胞抑制作用初步研究

Study on inhibitory effect of pickled garlic extracts on certain cancer cell lines

通过体外实验检测了醋蒜提取物对肿瘤细胞的抑制效果。采用MTT法检测醋蒜各提取物对HL-60人白血病细胞和MDA-MB人乳腺癌细胞的抑制作用;采用SRB法检测醋蒜提取物对BGC-823人胃癌细胞的抑制作用。醋蒜脂溶性成分对于所有受试的瘤株均表现出了抑制生长作用,对HL-60人白血病细胞和BGC-823人胃癌细胞,这部分提取物的抑制活性最强;水溶性提取物和醋蒜浸泡液同样具有一定的抗肿瘤活性,其对MDAMB435人乳腺癌细胞表现出较强的抑制作用。醋蒜的抗肿瘤活性组分得到较好保留。

Inhibitory effect on certain cancer cell lines of pickled garlic extracts was measured by MTT assay for leukemia cell HL-60 and breast carcinoma cell MDA-MB and SRB assay for gastric cancer cell BGC-823. The non-polar compounds in pickled garlic were still the most active factors, and exhibited highest activity for HL-60 and BGC-823 cell lines compared with other extracts. The aqueous extract and pickling solution also showed anticancer activity, especially highest for MDA-MB- 435 cells. Results showed that the active anticancer components were kept well after vinegar pickling.