反流性食管炎食管外表现与酸反流关系的研究

The association between extraesophageal manifestation of reflux esophagitis and acid reflux.

目的探讨反流性食管炎食管外表现与酸反流的关系。方法研究对象为2006年1月至2007年2月在卫生部北京医院消化科、呼吸科及耳鼻喉科门诊和住院的患者,均经胃镜检查证实为反流性食管炎(RE),具有烧心、反酸等胃食管反流和(或)RE的食管外症状(咳嗽、咽喉痛、咽部异物感、声音嘶哑等)。依据患者的主要症状分为食管外表现组及对照组(不具有食管外表现)。食管外表现组32例,对照组35例。所有患者在治疗前均进行24 h食管pH监测,并于治疗前、后对症状积分评定。所有患者均给予质子泵抑制剂(PPI)治疗。结果食管外表现组与对照组PPI治疗的有效率分别为86.4%与91.7%,差异无统计学意义(P>0.05)。结论反流性食管炎的食管外症状与酸反流显著相关。

Objective To investigate the association between extraesophageal syndromes of RE and acid reflux. Methods We investigated RE patients in Beijing hospital in the same time period. These patients were diagnosed with reflux esophagitis on endoscopy. In extraesophageal reflux disorders group（ 32 patients）and the control group（ 35 patients）, extraesophageal reflux disorders symptoms and the control symptoms were evaluated by questionnaire. All patients underwent 24 h esophageal pH monitoring and symptom score evaluation. All patients were treated with esomeprazole. Results The symptoms score in patients whose pH monitoring was positive were significantly decreased after treatments. In extraesopha- geal reflux disorders group,the effective rate was 86.4%. In control group,the effective rate was 91.7%. Conclusion Extraesophageal syndromes of RE are significantly associated with acid reflux.