急性冠脉综合征患者血清脂联素与C反应蛋白关系的研究

Association of serum adiponectin and C-reactive protein in patients with acinte coronary syndrome

目的探讨急性冠脉综合征(ACS)患者血清脂联素与C反应蛋白(CRP)的关系。方法临床及冠状动脉造影明确诊断的急性冠脉综合征患者50例,稳定型心绞痛(SAP)组21例和对照组15例,分别检测其血清脂联素、CRP水平,并进行比较。结果血清脂联素水平ACS组明显低于SAP组和对照组(P<0.01),CRP水平ACS组与SAP组和对照组比较有显著差异(P<0.01),而SAP组和对照组之间差异均无统计学意义。ACS患者血清脂联素水平随动脉粥样硬化程度的加重呈进行性下降。血清脂联素水平与冠状动脉的狭窄程度、CRP水平呈负相关。结论ACS患者血清脂联素水平降低,其与CRP之间的相互关系可能促进了动脉粥样硬化的发展。

Objective To determine the association between serum adiponectin and C-reactive protein（CRP） in patients with acinte coronary syndrome（ACS）. Methods Serum levels of adiponectin and CRP were measured in 50 patients with angiographically confirmed ACS group. 21 patients with the stable angina group and 15 control subjects with normal coronary angiogram （control group）. Result The levels of adiponectin significantly decreased and the levels of CRP significantly increased in ACS group, compared with the stable angina group and control group. There were no difference of adiponectin between SA group and control group. The level of adiponectin fell in parallel with the severity of coronary artery atherosclerosis in ACS group. Plasma adiponectin level was negatively correlated with the extent of coronary artery stenosis and CRP level. Conclusion The Serum levels of adiponectin significantly decrease in ACS grouo,which association with CRP may oromote the develooment of atheroscleros is.