nm23基因在涎腺恶性肿瘤中表达的意义

Significance of nm23 expression in malignant carcinoma of salivary gland

为了探讨ｎｍ２３基因在涎腺恶性肿瘤中表达的意义，作者应用免疫组织化学方法检测了４０例涎腺恶性肿瘤ｎｍ２３基因表达情况，并分析了ｎｍ２３基因表达变化与涎腺恶性肿瘤的临床病理及其转移的关系。结果发现，ｎｍ２３低表达者其肿瘤转移率为８１８％，而ｎｍ２３高表达者其肿瘤转移率只有３４％，两者差异有高度显著性（Ｐ＜０．００５）；ｎｍ２３低表达与肿瘤大小、部位、病理类型无显著相关性（Ｐ＞０．０５）。结果表明ｎｍ２３基因在抑制涎腺恶性肿瘤转移方面起重要作用。

In recent years, a tumor suppressor gene nm23 has been found to be associated with decreased tumor metastatic potential. Allelic deletion, mutation and low expression of this gene has been correlated with tumor metastatic potential in a number of tumors. We examined the expression of nm23 in 40 cases of salivary gland malignant carcinomas by immunohistochemical method. The results showed that nm23 lower expression tumors were associated with a higher rate of metastasis (81.8%) than nm23 higher expression (3.4%, P<0.005). There is no correlation between nm23 lower expression and tumor size, location and pathologic type (P>0.05). This result indicates that nm23 gene plays an important role in the metastasis of salivary gland malignant carcinoma.