摘要
通过观察服用固齿膏后龈沟液(gingivalcrevicularfluid,GCF)中白细胞介素8(IL8)的变化,目的为探讨中药固齿膏与细胞因子间的关系。选成人牙周炎患者24人,每人口中选患牙1个,龈上洁治后随机分为两组,一组服用固齿膏,另一组不服用任何药物,1个月后复诊。用酶联免疫检测(ELISA)法检测龈沟液中IL8水平。结果表明,服药组1个月后龈沟液中IL8水平和龈沟液量显著下降,而未服药组的IL8水平和龈沟液量与治疗前无显著差别。提示固齿膏对IL8和龈沟液的产生有抑制作用。
In order to find a new treatment of periodontitis, this paper studied the effects of Gu Chi Gao on IL8 in gingival crevicular fluid (GCF) of periodontitis. One tooth was selected from every patient in 24 patients with adult periodontitis. After supragingival scaling, the patients were divided into two groups randomly. One group was treated with Gu Chi Gao, while the other group was untreated as control group. All patients were examined after one month. GCF samples were collected with 2 mm×20 mm Whatman I filter paper stripes and IL8 in the GCF samples were detected by the method of ELISA. The result demonstrated that the levels of GCF and IL8 in the treated group were lower than that of control group (P<0.01), if suggest, that Gu Chi Gao may inhibit the production of IL8 and GCF.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1997年第6期373-374,共2页
Chinese Journal of Stomatology