固齿膏对牙周炎龈沟液中IL-8的影响

The effects of Gu Chi Gao on IL8 in GCF of periodontitis

通过观察服用固齿膏后龈沟液（ｇｉｎｇｉｖａｌｃｒｅｖｉｃｕｌａｒｆｌｕｉｄ，ＧＣＦ）中白细胞介素８（ＩＬ８）的变化，目的为探讨中药固齿膏与细胞因子间的关系。选成人牙周炎患者２４人，每人口中选患牙１个，龈上洁治后随机分为两组，一组服用固齿膏，另一组不服用任何药物，１个月后复诊。用酶联免疫检测（ＥＬＩＳＡ）法检测龈沟液中ＩＬ８水平。结果表明，服药组１个月后龈沟液中ＩＬ８水平和龈沟液量显著下降，而未服药组的ＩＬ８水平和龈沟液量与治疗前无显著差别。提示固齿膏对ＩＬ８和龈沟液的产生有抑制作用。

In order to find a new treatment of periodontitis, this paper studied the effects of Gu Chi Gao on IL8 in gingival crevicular fluid (GCF) of periodontitis. One tooth was selected from every patient in 24 patients with adult periodontitis. After supragingival scaling, the patients were divided into two groups randomly. One group was treated with Gu Chi Gao, while the other group was untreated as control group. All patients were examined after one month. GCF samples were collected with 2 mm×20 mm Whatman I filter paper stripes and IL8 in the GCF samples were detected by the method of ELISA. The result demonstrated that the levels of GCF and IL8 in the treated group were lower than that of control group (P<0.01), if suggest, that Gu Chi Gao may inhibit the production of IL8 and GCF.