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行为遗传学的终结?(英文)

The End of Behavioral Genetics?
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摘要 虽然遗传研究在20世纪初期的心理学里呈上升趋势,早期行为遗传学与优生学的襟带关系使这个学科蒙上阴影。20世纪下半叶的双生子和养子女的研究重新树立了该学科的威信,并为现今的遗传与环境互动的研究奠定了基础。本文以发展行为遗传学、遗传环境互动以及用行为遗传学来验证因果关系的研究为例,来突显这一学科对心理学的贡献。今后遗传与环境互动的研究将更侧重于辨识"候选基因"的技术。"全基因组关联"的研究为未来行为遗传学的发展提供了一个乐观的前景。 Although genetic models were in the ascendance within psychology during the early 20th century, the association of early behavioral genetic research with the eugenics movement served to discredit the field in the eyes of many. Twin and adoption studies throughout the latter half of the 20th century helped to reestablish the importance of behavioral genetic models and set the stage for the current focus of the field on developing and testing models of gene-environment interplay. Research findings on developmental behavioral genetic research, gene-environment interaction, and the use of behavioral genetic models to test causal hypotheses are used to highlight the contributions of contemporary behavioral genetic research to psychological research. It is argued that future efforts to investigate models of gene-environment interplay will depend heavily on the field's ability to identify the specific genetic variants that contribute to individual differences in behavior. The anticipated yield from genome-wide association studies gives much genetics. reason to be optimistic about the future vitality of behavior
作者 Matt McGue
出处 《心理学报》 CSSCI CSCD 北大核心 2008年第10期1073-1087,共15页 Acta Psychologica Sinica
基金 This paper is based in part on a presentation given at the 2008 biennial meeting of the Society for Research on Adolescence in Chicago Illinois.Research reported herein was supported in part from the following grants from the U.S. National Institutes of Health: AA09367, AA11886, DA05147, and MH066140
关键词 优生学 双生子和养子女研究 遗传环境交互作用 自然实验 高尔顿 Eugenics twin and adoption research gene-environment interplay natural experiments Galton
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  • 1Ando, J., Nonaka, K., Ozaki, K., Sato, N., Fujisawa, K. K., Suzuki, K., et al. (2006). The Tokyo Twin Cohort Project: Overview and initial findings. Twin Research and Human Genetics, 9(6), 817-826.
  • 2Bergen, S. E., Gardner, C. O., & Kendler, K. S. (2007). Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: A meta-analysis. Twin Research and Human Genetics, 10(3), 423-433.
  • 3Bierut, L. J., Madden, P. A. F., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O. F., et al. (2007). Novel genes identified in a high-density genome wide association study for nicotine dependence. Human Molecular Genetics, 16(1), 24-35.
  • 4Blum, K., Noble, E. P., Sheridan, P. J., Montgomery, A., Ritchie, T., Jagadeeswaran, P., et al. (1990). Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA, 263(15), 2055-2060.
  • 5Bouchard, T. J., & McGue, M. (1981). Familial studies of intelligence: A review. Science, 212(4498), 1055-1059.
  • 6Bouchard, T. J., Lykken, D. T., McGue, M., Segal, N., & Tellegen, A. (1990). Sources of human psychological differences: The Minnesota Study of Twins Reared Apart. Science, 250, 223-228.
  • 7Burmeister, M., McInnis, M. G., & Zollner, S. (2008). Psychiatric genetics: progress amid controversy. Nature Reviews Genetics, 9(7), 527-540.
  • 8Busjahn, A., & Hur, Y. M. (2006). Twin registries: An ongoing success story. Twin Research and Human Genetics, 9(6), 705-705.
  • 9Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851-854.
  • 10Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I., Harrington, H. L., et al. (2003). Influence of life stress on depression: Moderation by polymorphism in the 5-HTT gene. Science, 301, 386-389.

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