血清性激素在原发性高血压病中的作用研究

Study on the reaction between serum sex hormones levels and essential hypertension

目的:探讨原发性高血压(EH)发病与血清性激素之间存在的作用关系。方法:用化学发光免疫法测定47例男性EH患者及45例女性绝经后EH患者和相应正常对照组的血清性激素(LH、FSH、E2、P、T)水平,并进行高血压分期对照分析。结果:男、女EH患者血清E2、P、T水平均显著高于对照组(P<0.01);血清LH、FSH水平均低于对照组,其中男性EH组FSH水平和对照组相比下降不明显(P>0.05)。Ⅰ、Ⅱ、Ⅲ期EH患者性激素水平经F检验无显著差异(P>0.05)。相关分析显示,男性EH组E2水平和女性EH组P水平与FSH、LH水平变化无明显相关关系(P>0.05)。结论:EH患者血清E2、P、T水平显著高于对照组,且E2、P与FSH、LH之间无相关关系,Ⅰ、Ⅱ、Ⅲ期之间性激素水平无显著差异。血清性激素水平的变化可能是一个高血压的危险因子,可作为EH病部分病因的推测和提示。

Objective ： To investigate the possible relationship existing between serum sex hormones levels development of essential hypertension. Methods： Serum sex hormones （LH, FSH, E2, P, T） levels were determined with chemiluminescence immunoassay in 47 males and 45 post-menopausal women with essential hypertension as well as in 44 normotensive males and 40 normotenisive post-menopausal women serving as controls. Results The serum E2, progesterone and testosterone levels in the hypertensive were significantly higher than those in the respective controls （P 〈0. 01）, while serum LH and FSH levels were significantly lower with the exception of serum FSH in male hypertensive （vs controls, P〉0. 05）. Sex hormones levels were not much different among hypertensive of various stages （ Ⅰ , Ⅱ, Ⅲ）. The serum E2 levels in male hypertensive and progesterone levels in female hypertensive were not correlated with the respective FSH and LH levels. Conclusion： The authors suggest that the changes of serum sex hormones levels might be a risk factor rather than a consequence of the development of essential hypertension.