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幽门螺杆菌CagA蛋白研究进展 被引量：11

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作者 汪苏 周建奖 单可人
机构地区 贵阳医学院分子生物学重点实验室
出处 《微生物与感染》 2008年第3期175-177,189,共4页 Journal of Microbes and Infections
基金 国家自然科学基金资助项目(30560038) 贵州省科技技术基金项目[黔科合丁字(2007)2084]
关键词 幽门螺杆菌 A蛋白 Cag 胃部疾病 上皮细胞 酪氨酸磷酸化 分泌系统 C-ABL
分类号 R378 [医药卫生—病原生物学]
  • 相关文献

参考文献15

  • 1Selbach M, Moese S, Hauck CR, et al. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem, 2002,277 : 6775 - 6778
  • 2Higashi H, Tsutsumi R, Fujita A, et al. Biological activity of the Helieobaeter pylori virulence factor CagA is determined by variation in the tymsine phosphorylation sites. Proc Natl Acad Sci USA ,2002,99: 14428- 14433
  • 3Kwok T, Zabler D, Urman S, et al. Helicobacter exploits integrin for type Ⅳ secretion and kinase activation . Nature, 2007,449 : 862 - 867
  • 4Tsutsumi R, Higashi H, Higuchi M, et al. Attenuation of Helicobaeter pylori CagA-SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem,2003, 278: 3664 - 3670
  • 5Higashi H, Tsutsumi R, Muto S, et al. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylofi CagA protein. Science, 2002,295 : 683 - 686
  • 6Saadat I, Higashi H, Obusu C, et al. Helicobacter pylori CagA targets PAR1/MAPK kinase to disrupt epithelial cell polartity. Nature, 2007,447 : 330 - 333
  • 7Tsutsumi R, Takahashi A, Azuma T, et al. Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol, 2006,26: 261 -276
  • 8Tammer I, Brandt S, Hartig R, et al. Activation of Abl by Helicobacter pylori: A novel kinase for CagA and crucial mediator of host cel 1 scattering. Gastroenterology, 2007, 132 : 1309- 1319
  • 9Poppe M, Feller SM, Romer G, et al. Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oneogene,2007,26:3462 - 3472
  • 10Roovers K, Assoian RK. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays,2000,22:818 826

同被引文献77

  • 1徐建华,朱家勇.生物信息学在蛋白质结构与功能预测中的应用[J].医学分子生物学杂志,2005,2(3):227-232. 被引量：44
  • 2赵富玺,涂德照.病原生物与免疫学[M].7版.北京:人民卫生出版社,2007:369-373.
  • 3叶任高，陆再英.内科学[M].5版．北京：人民卫生出版社,2002：258—260
  • 4Lau JY, Sung J, Hill C, et al. Systematic review of the epidemi- ology of complicated peptic ulcer disease : incidence, recurrence, risk factors and mortality [ J ]. Digestion, 2011,84 : 102 - 113.
  • 5Hsiao FY, Tsai YW, Wen YW, et al. Effect of Helicobacter py- lori eradication therapy on risk of hospitalization for a major ulcer event [ J ]. Pharmacotherapy, 2011,31 ..239 - 247.
  • 6Gen6 E, Sanchez-Delgado J, Calvet X, et al. What is the best strategy for diagnosis and treatment of Helicobacter pylori in the prevention of recurrent peptic ulcer bleeding? A cost-effective- ness analysis[ J ]. Value Health, 2009,12:759 - 762.
  • 7Nuhu A, Madziga AG, Gali BM. Acute perforated duodenal ul- cer in Maiduguri: experience with simple closure and Helico- bacter pylorieradication[ J]. West Afr J Med, 2009,28:384 - 387.
  • 8Kenneth El Mccoll. Helicobacter pylori infection[J]. N Engl J Med, 2010,362 ( 17 ) : 1597.
  • 9Lacasse EC, Mahoney D J, Cheung HH,et al. IAP-targeted ther-apies for cancer r 1- Oncogene, 2008,27(48) :6252 -6276.
  • 10Ran Tao Miao-Feng Hu Jin-Tu Lou Yong-Liang Lei.Effects of H pylori infection on gap-junctional intercellular communication and proliferation of gastric epithelial cells in vitro[J].World Journal of Gastroenterology,2007,13(41):5497-5500. 被引量：8

引证文献11

二级引证文献62

微生物与感染
2008年 第3期

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