对称三唑Schiff碱与铜的配合物合成及性能

Syntheses and Properties of Copper Complexes of Symmetrical Triazole Schiff Bases

合成了４种新型对称三唑水杨醛Ｓｃｈｉｆ碱的铜配合物［ＣｕＬ１Ｃｌ２］（Ⅰ）和三核配合物［Ｃｕ３（Ｌ２－Ｌ４）２Ｃｌ４］·ｎＨ２Ｏ（Ⅱ～Ⅳ），其中Ｌ１，Ｌ２，Ｌ３和Ｌ４分别为４－氨基－１，２，４－三唑、４－氨基－３，５－二甲基－１，２，４－三唑、４－氨基－３，５－二乙基－１，２，４－三唑和４－氨基－３，５－二羟甲基－１，２，４－三唑的水杨醛Ｓｃｈｉｆｆ碱．经元素分析、电导、红外光谱、热重分析、电子光谱、ＥＳＲ和变温磁化率表征，该类配合物为畸变四方构型．配合物Ⅱ的变温磁化率表明，铜离子间存在弱的反铁磁相互作用，Ｊ＝－１８．９ｃｍ－１，ｇ＝２．０８，Ｆ＝２．７×１０－３．配合物对Ｂ细胞增殖有抑制作用．

Four copper(Ⅱ) complexes of Schiff bases of symmetical triazole and salicylaldehyde were synthesized, namely[Cu(L 1)Cl 2](Ⅰ) and trinuclear complexes [Cu 3(L 2￣L 4) 2Cl 4]· n H 2O(Ⅱ￣Ⅳ) where L 1, L 2, L 3 L 4 are Schiff bases of 4 amino 1,2,4 triazole, 4 amino 3,5 dimethyl 1,2,4 triazole, 4 animo 3,5 diethyl 1,2,4 triazole and 4 amino 3,5 dihydroxymethyl 1,2,4 triazole, respectively. The complexes were characterized by elemental analysis, conductivity, IR spectrum, thermoanalysis, electronic spectrum, ESR and susceptibility measurements. The complexes have been proposed to have distorted square configuration. The results of variable temperature magnetic susceptibility of complex(Ⅱ) indicated the weak antiferromagnetic spin exchange interaction between the copper(Ⅱ) ions. J = -18 9 cm -1 , g =2 08, F =2 7×10 -3 . The biological activity tests of the complexes showed that they are capable of inhibiting B cell.