摘要
在0.1mol/LNH4Ac(pH7.8)底液中,氯氮平(CLP)在汞电极上有一线性扫描还原峰,Epc=-1.34V(vs.Ag/AgCl).该峰具有明显的吸附性,吸附粒子为CLP中性分子.测得CLP在汞电极上的饱和吸附量为2.7×10-10mol/cm2,每个CLP分子所占电极面积为0.62nm2,CLP在悬汞电极上的吸附符合Frumkin等温式.测得吸附系数β=6.28×105,吸引因素γ=0.75,电子转移数n为2,不可逆吸附的转移系数α为0.53.探讨了CLP在汞电极上的还原机理,并建立了吸附溶出伏安法测定CLP的最佳条件,检测限为8.0×10-9mol/L.
In a supporting electrolyte containing 0 1 mol/L NH 4Ac(pH 7 8), a reduction peak of clozapine(CLP) was found by linear sweep voltammetry at Hg electrode. The peak shows a potential of -1 34 V( vs Ag/AgCl) and adsorptive characteristics. When the concentration of CLP is sufficiently low, the sweep rate is sufficiently rapid and the accumulation time is sufficiently long, the peak current is totally contributed by the reduction of the adsorbed CLP. The adsorbed species is most probably neutral molecules of CLP. The saturated adsorption amount of CLP at Hg electrode is 2 7×10 -10 mol/cm 2 and every CLP molecule occupies 0 62 nm 2. On the surface of HMDE, the adsorption of CLP obeys Frumkin adsorption isotherm. The adsorption coefficient is 6 28×10 5, the attractive factor is 0 75. The number of electrons transferred per CLP molecule, n , is 2 and the transfer coefficient of the irreversible adsorptive system of CLP is 0 53. The mechanism of electrochemical reduction of CLP at Hg electrode has been explored. The detection limit of the adsorptive stripping voltammetry of CLP is 8 0×10 -9 mol/L under optimum condition.
出处
《应用化学》
CAS
CSCD
北大核心
1997年第3期53-57,共5页
Chinese Journal of Applied Chemistry
关键词
氯氮平
电化学行为
CLP
抗精神病药
clozapine,adsorptive stripping voltammetry,electrochemical characteristics