制备1-氰基-2,3,5-三-O-苯甲酰基-β-D-呋喃核糖的简便方法

Synthesis of 1 Cyano 2,3,5 tri O benzoyl β D ribofuranose

制备１┐氰基┐２，３，５┐三┐Ｏ┐苯甲酰基┐β┐Ｄ┐呋喃核糖的简便方法张万轩＊雷策南黄锦霞陈家威（湖北大学化学系武汉４３００６２）关键词鸟苷，制备，氰基三苯甲酰基－β－Ｄ－呋喃核糖，三甲基氯硅烷１９９６－０８－１２收稿，１９９７－０３－０５修回１－氰...

Reacting guanosine with benzoyl chloride gave a mixture containing 2,3,5 tribenzoyl guanosine. After distillation in vacuum the residual solid was acetylated directly and 1 O acetyl 2,3,5 tri O benzoyl β D ribofuranose (2) was obtained. Being reacted with Me 3SiCN, (2) led to the title compound(1). The method reported here is more convenient and cheaper with a considerably higher yield.