成都市区健康体检人群乙型肝炎病毒血清学标志检测结果分析

Analysis on Serological Markers of HBV Among Urban Residents of Chengdu City

目的分析成都市区健康体检人群中乙型肝炎病毒(HBV)血清学标志(HBVm)阳性结果、分布情况及可能的影响因素,增强人们对HBV感染的认知能力,合理干预,提高人们对乙型肝炎的自觉免疫意识。方法对2007-07-01/2008-06-30在四川省人民医院健康体检中心体检的108685名成都市区人群进行乙肝病毒表面抗原(HB-sAg)、乙肝病毒表面抗体(HBsAb)、乙肝病毒e抗原(HBeAg)、乙肝病毒e抗体(HBeAb)、乙肝病毒核心抗体(HB-cAb)及肝功能进行检测,同时调查HBV感染过去史、家族史、乙肝疫苗预防接种史。结果HBVm阴性31063人,占28.58%;HBsAg、HBeAg、HBcAb均阳性者4637人,阳性率4.27%;HBsAg、HBeAb、HBcAb均阳性者5250人,阳性率4.83%;HBsAg、HBcAb均阳性者527人,阳性率0.48%;单纯HBsAb阳性51228人,阳性率47.13%;HB-sAb、HBeAb、HBcAb均阳性者1921人,阳性率1.77%;HBsAb、HBcAb均阳性者13200人,阳性率12.15%;其他(HBeAb、HBcAb阳性、单纯HBeAb、单纯HBcAb阳性)共859人,阳性率0.79%;肝功异常(单项转氨酶和/或两项转氨酶增高)共计896人,异常率为0.82%;乙肝疫苗预防接种33779人;接种率31.08%。结论成都市区乙肝表面抗原携带总人数或阳性率与全国水平接近,而乙肝疫苗接种率较低。加强乙肝保健知识健康教育,强化乙肝疫苗接种是进一步降低乙型肝炎病毒感染率的最有效的手段。

Objective To analyze the positive results of HBVm （ serological markers of HBV） and its distribution and possible influential factors from physical examination among residents in urban area of Chengdu City, so as to improve the eognizing ability of common people to hepatitis B infection, and to enrich the people＇s immune sense to hepatitis B. Method Testing of HBsAg, HBsAb, HBeAg, HBeAb and HBeAb as well as liver function were carried out among 108 685 people in urban area of Chengdu City who took physical examinations in the Physieal Examination Center of Sichuan Provincial Hospital from July 1, 2007 to June 30, 2008. Meantime, the past history, family history, vaccinating history of hepatitis B virus （HBV）infection were investigated. Results The results （No. person and percentage） were as follows： HBVm negative 31 063, 28.58%, HBsAg/HBeAg/HBcAb positive 4 637, 4.27% ; HBsAg/HBeAb/HBcAb positive 5 250, 4.83%, HBsAg/HBcAb positive 527, 0.48%, sing＇le HBsAb positive 51 228, 47.13%, HBsAb/ HBeAb/HBcAb positive 1921, 1.77%, HBsAb/HBcAb positive 13 200, 12. 15%, and others （HBeAb/ HBcAb positive, only HBeAb positive or only HBcAb positive） 896, abnormal rate 0. 82%. Abnormal liver function （single higher transaminase and/or double higher transaminase） revealed in 896 Persons with an abnormal rate of O. 82%. Vaccinating of hepatitis B virus （HBV） was conducted in 33 779 persons with a, vaccinating rate of 31.08%. Conclusion In urban area of Chengdu city, HBsAg carriers and HBsAg positive rate is close to national average level. But vaccinating rate of HBV would be relatively low. To strengthen health education on HBV and to expand the vaccinating rate of HBV, is the most effective method to further decrease the infection rate of hepatitis B virus.